Detalle de: Structure / Activity Relationship of Carba- and C-Fucopyranosides as Inhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies
| Title | Structure / Activity Relationship of Carba- and C-Fucopyranosides as Inhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies |
| Abstract |
Several carba- and C-fucopyranosides have been tested as inhibitors of recombinant α 1,6- Fucosyltransferase from Rhizobium sp. 1-(R)-amino-phenylmethyl C-fucopyranoside (7) with 4C1(L) conformation showed the highest inhibition (IC50 = 690 μM). Molecular modeling alloweded us to establish an structure/activity relationship for the carba- and C-fucopyranosides inhibition activity. Keywords: glycosyltransferases, inhibitors, c-glycosides, carbocycles, molecular mechanics calculations |
| Apa Reference | Calderon, F., Carpintero, M., Garcia-Junceda, E., Fernandez-Mayoralas, A. & Bastida, A. (2005). Structure / Activity Relationship of Carba- and C-Fucopyranosides as Inhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies. Letters in Organic Chemistry, 2(3), 247-251. 10.2174/1570178053765393 |
| Doi | 10.2174/1570178053765393 |
| Publication Date | 1 May 2005 |
| Publication Type | Article |
| Researcher | Agatha Bastida |
| Ontology | Drug Discovery and design |
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