Detalle de: Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids
| Title | Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids |
| Abstract |
[reaction: see text] The base-promoted cyclization of optically pure N-(p-methoxybenzyl)-N-(2-chloro)propionyl amino acid derivatives resulted in a diastereo- and enantioselective approach to valuable 1,3,4,4-tetrasubstituted beta-lactams. The stereochemical outcome of the reaction is exclusively governed by the configuration of the N-(2-chloro)propionyl moiety. |
| Apa Reference | Pérez-Faginas, P., O'Reilly, F., O'Byrne, A., García-Aparicio, C., Martín-Martínez, M., Pérez de Vega, M.J., García-López, M.T. & González-Muñiz, R. (2007). Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids. Organic Letters, 9(8), 1593-1596. 10.1021/ol070533d |
| Doi | 10.1021/ol070533d |
| Publication Date | 24 Mar 2007 |
| Publication Type | Article |
| Researcher | Mercedes Martín Martínez |
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