Mercedes Martín Martínez
Peptidomimetics · IQM
Biography
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Tenured Scientist (Científica Titular) at the Instituto de Química Médica (IQM-CSIC), Department of Biomimetics for Drug Discovery, in the Peptidomimetics group. Principal investigator, together with Rosario González Muñiz, of the projects "Dimorfismo sexual en migraña: thermoTRPS como dianas de hormonas y fármacos" (PID2021-126423OB-C22, 2022-2025) and "Señalización mediada por el sexo y el medioambiente en la migraña crónica: mecanismos, biomarcadores y estrategias terapéuticas" (PID2024-160392OB-C22, 2024-2026). (Description curated from publicly available data.) |
Profile
| Institution | IQM |
| Position | Tenured Scientist |
| Home page | https://www.iqm.csic.es/personal/mercedes-martin-martinez/ |
| Contact email | mmartin@iqm.csic.es |
| ORCID | 0000-0002-6449-0905 |
BCB Hub
| BCB Committee | Talent attraction and training, Teaching links with University |
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Research
Research topics
Computational MethodsApplications of Computational BiologyStructural bioinformaticsMutation Analysis and designStructure-function relationshipDrug Discovery and designStructure predictionMolecular Interactions/DockingProtein-Protein Interactions
Research lines
Projects, networks, transfer & teaching
Teaching
Master programs
- MSc in Computational Biology - Universidad Politécnica de Madrid - https://www.etsiaab.upm.es/Docencia/Masteres/Especializacion/Biologia_computacional (BCB coordinator)
Publications 59 entries
- In Silico Decoding of Nonsteroidal Mineralocorticoid Receptor Antagonist Binding: Implications for Drug Design Article · 15 Aug 2026
- The WIPI homolog Atg18 binds to and tethers membranes containing phosphatidylinositol-3,4,5-triphosphate Preprint · 4 Feb 2025
- β-Turn Induction by a Diastereopure Azepane-Derived Quaternary Amino Acid Article · 29 Sep 2023
- IQM-22110, a new selective inhibitor of KChIP3 and its electrophysiological effects on Kv4.3, Kv4.3/KChIP3 and Kv4.3/KChIP2 currents Article · Feb 2023
- Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists Article · 26 Jan 2023
View all (54 more)
- Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands Article · 17 Aug 2022
- Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2 Article · 15 Aug 2022
- Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond Article · Aug 2022
- DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target Article · Oct 2021
- TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation Article · 7 Aug 2021
- Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators Article · Feb 2021
- Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs Article · 31 Jan 2021
- Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington’s disease treatment Article · 13 May 2019
- Varied Presentation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Needs for Classification and Clinician Education: A Case Series Article · Apr 2019
- Corrigendum to Supplemental Material: ‘D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence’ [Journal of Molecular and Cellular Cardiology, Volume 110, September 2017, Pages 61–69] Article · Mar 2019
- Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents Article · 4 Feb 2019
- IKs Computational Modeling to Enforce the Investigation of D242N, a KV7.1 LQTS Mutation Conference paper · 14 Sep 2017
- D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence Article · Sep 2017
- Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities Article · Apr 2017
- Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects Article · 24 Jan 2017
- Divergent, stereoselective access to heterocyclic α,α-quaternary- and β 2,3,3 -amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam Article · 2015
- Experimental and Theoretical Studies on the Rearrangement of 2‐Oxoazepane α,α‐Amino Acids into 2′‐Oxopiperidine β 2,3,3 ‐Amino Acids: An Example of Intramolecular Catalysis Article · 17 Dec 2014
- De Novo Designed Library of Linear Helical Peptides: An Exploratory Tool in the Discovery of Protein–Protein Interaction Modulators Article · 22 Apr 2014
- Helical peptides from VEGF and Vammin hotspots for modulating the VEGF–VEGFR interaction Article · 2013
- Azepane Quaternary Amino Acids As Effective Inducers of 3 10 Helix Conformations Article · 22 Oct 2012
- Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor Article · Jan 2012
- Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation Article · Dec 2011
- Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides Article · 18 Jul 2011
- Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF81–91: Potential biological tools for studying the VEGF/VEGFR-1 interaction Article · Mar 2011
- 2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments Article · 2 Apr 2010
- Further Evidence for 2-Alkyl-2-carboxyazetidines as γ-Turn Inducers Article · 1 Oct 2009
- Exploring the binding pocket for pyridopyrimidine ligands at the CCK1 receptor by molecular docking Article · 20 Feb 2008
- Azetidine-Derived Amino Acids versus Proline Derivatives. Alternative Trends in Reverse Turn Induction Article · 25 Jan 2008
- Strategies for Design of Non Peptide CCK1R Agonist/Antagonist Ligands Article · 1 Jun 2007
- 2-Alkyl-2-carboxy-azetidines as scaffolds for the induction of γ-turns Article · May 2007
- Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids Article · 24 Mar 2007
- Modulation of Protein-Protein Interactions by Stabilizing/Mimicking Protein Secondary Structure Elements Article · 1 Jan 2007
- The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity Article · Jul 2006
- Stereoselective synthesis of amino acid-derived β-lactams. Experimental evidence for TADDOL as a memory of chirality enhancer Article · Jan 2006
- Conformationally Constrained CCK4 Analogues Incorporating IBTM and BTD β-Turn Mimetics Article · 2 Nov 2005
- Combination of Molecular Modeling, Site-Directed Mutagenesis, and SAR Studies To Delineate the Binding Site of Pyridopyrimidine Antagonists on the Human CCK1 Receptor Article · 1 Jul 2005
- Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships Article · May 2005
- Synthesis, Conformational Analysis, and Cytotoxicity of Conformationally Constrained Aplidine and Tamandarin A Analogues Incorporating a Spirolactam β-Turn Mimetic Article · 30 Sep 2004
- Gly-Pro-Glu protects β-amyloid-induced somatostatin depletion in the rat cortex Article · Aug 2004
- Memory of chirality in the stereoselective synthesis of β-lactams: importance of the starting amino acid derivative Article · Aug 2003
- Effects of the incorporation of IBTM β-turn mimetics into the dipeptoid CCK1 receptor agonist PD 170292 Article · Jan 2002
- Conformationally restricted PACAP27 analogues incorporating type II/II′ IBTM β-Turn Mimetics. Synthesis, NMR Structure Determination, and Binding Affinity Article · Dec 2001
- 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2- c ]pyrimidine-Based Potent and Selective CCK 1 Receptor Antagonists: Structure−Activity Relationship Studies on the Substituent at N2-Position Article · 25 May 2001
- β-Turned Dipeptoids as Potent and Selective CCK 1 Receptor Antagonists Article · 9 Sep 2000
- Studies on the synthesis of β-keto esters derived from dipeptides: search for a low-epimerizing method Article · May 2000
- Highly constrained dipeptoid analogues containing a type II′ β-turn mimic as novel and selective CCK-A receptor ligands Article · Jan 1999
- An iterative structure-assisted approach to sequence alignment and comparative modeling Article · 1999
- Synthesis and Stereochemical Structure−Activity Relationships of 1,3-Dioxoperhydropyrido[1,2- c ]pyrimidine Derivatives: Potent and Selective Cholecystokinin-A Receptor Antagonists Article · 1 Oct 1997
- Pharmacological evaluation of IQM‐95,333, a highly selective CCK A receptor antagonist with anxiolytic‐like activity in animal models Article · Jun 1997
- Bicyclic lactams as templates for peptidomimetics. Studies on stereoselective synthetic routes to 6-oxoperhydropyrrolo[1,2-a]pyrazines Article · Oct 1996
- Synthesis of highly functionalized γ-lactam derivatives for use as conformational constraints in peptides Article · Apr 1996
- CCK-4 restricted analogues containing a 3-oxoindolizidine skeleton Article · Apr 1996
- 3,6-dioxoperhydropyrrolo[1,2-a]pyrazines as templates for peptidomimetics Article · Sep 1995
- 3,6-dioxoperhydropyrrolo[1,2-a]pyrazines. A new approach to conformationally restricted tripeptides Article · Apr 1992