Detalle de: Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships
| Title | Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships |
| Abstract |
A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important. |
| Apa Reference | Alonso De Diego, S.A., Muñoz, P., González-Muñiz, R., Herranz, R., Martín-Martínez, M., Cenarruzabeitia, E., Frechilla, D., Del Río, J., Luisa Jimeno, M. & Teresa García-López, M. (2005). Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships. Bioorganic & Medicinal Chemistry Letters, 15(9), 2279-2283. 10.1016/j.bmcl.2005.03.015 |
| Doi | 10.1016/j.bmcl.2005.03.015 |
| Publication Date | May 2005 |
| Publication Type | Article |
| Researcher | Mercedes Martín Martínez |
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