Detalle de: Highly constrained dipeptoid analogues containing a type II′ β-turn mimic as novel and selective CCK-A receptor ligands
| Title | Highly constrained dipeptoid analogues containing a type II′ β-turn mimic as novel and selective CCK-A receptor ligands |
| Abstract |
Conformationally constrained dipeptoid analogues containing the type II' beta-turn mimic (2S,5s,11bR)-2-amino-3-oxohexahydroindolizino[8,7-b]indole-5 -carboxylate framework in place of the alpha-MeTrp residue, show high binding affinity and selectivity for CCK-A receptors, suggesting that a turn-like conformation could contribute to the bioactive conformation at this CCK receptor subtype. |
| Apa Reference | Figuera, N.d.l., Martín-Martínez, M., Herranz, R., Teresa García-López, M., Latorre, M., Cenarruzabeitia, E., del Río, J. & González-Muñiz, R. (1999). Highly constrained dipeptoid analogues containing a type II′ β-turn mimic as novel and selective CCK-A receptor ligands. Bioorganic & Medicinal Chemistry Letters, 9(1), 43-48. 10.1016/S0960-894X(98)00677-5 |
| Doi | 10.1016/S0960-894X(98)00677-5 |
| Publication Date | Jan 1999 |
| Publication Type | Article |
| Researcher | Mercedes Martín Martínez |
| Ontology | Molecular flexibility, Molecular Interactions/Docking |
| Research Groups | |
| Tools |