Detalle de: Effects of the incorporation of IBTM β-turn mimetics into the dipeptoid CCK1 receptor agonist PD 170292
| Title | Effects of the incorporation of IBTM β-turn mimetics into the dipeptoid CCK1 receptor agonist PD 170292 |
| Abstract |
Replacement of the 2-Adoc-D-alphaMeTrp residue in the non-selective CCK(1) receptor agonist PD 170292 by the Z-(2R,5R,11bS)-IBTM skeleton, able to fix a type II beta-turn-like conformation, led to a conformationally restricted dipeptoid analogue, namely 3a, which exhibited a notable increase in the CCK(1) selectivity and antagonist properties. |
| Apa Reference | Martı́n-Martı́nez, M., Latorre, M., Garcı́a-López, M., Cenarruzabeitia, E., Del Rı́o, J. & González-Muñiz, R. (2002). Effects of the incorporation of IBTM β-turn mimetics into the dipeptoid CCK1 receptor agonist PD 170292. Bioorganic & Medicinal Chemistry Letters, 12(2), 109-112. 10.1016/S0960-894X(01)00630-8 |
| Doi | 10.1016/S0960-894X(01)00630-8 |
| Publication Date | Jan 2002 |
| Publication Type | Article |
| Researcher | Mercedes Martín Martínez |
| Ontology | Molecular flexibility |
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