Detalle de: Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle
| Title | Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle |
| Abstract |
The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of "missing heritability"--the proportion of additive genetic variation not captured by common variants on SNP arrays. Sequence variants in transcript and regulatory regions from 429 sequenced animals were used to impute high density SNP genotypes of 3311 Holstein sires to sequence. There were 675,062 common variants (MAF>0.05), 102,549 uncommon variants (0.01 |
| Apa Reference | Gonzalez-Recio, O., Daetwyler, H.D., MacLeod, I.M., Pryce, J.E., Bowman, P.J., Hayes, B.J. & Goddard, M.E. (2015). Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle. PLOS ONE, 10(12), e0143945. 10.1371/journal.pone.0143945 |
| Doi | 10.1371/journal.pone.0143945 |
| Publication Date | 7 Dec 2015 |
| Publication Type | Article |
| Researcher | Oscar Gonzalez-Recio |
| Ontology | Genomics, Statistical Methods for Biology, Population genomics, Sequence error correction, Quantitative genetics |
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