Detalle de: Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection
| Title | Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection |
| Abstract |
Clonal variants of Mycobacterium tuberculosis (MTB) coexist in specific patients, although the dynamics of their emergence is unknown. We used MIRU-VNTR to detect microevolution leading to variants of MTB in 3 out of 19 patients (15%) soon after diagnosis (61-85days). Most harbored SNPs and for some of them a potential functional role was suggested. Microevolution in tuberculosis seems to occur sooner and more often than expected and could affect tracking of transmission. |
| Apa Reference | Pérez-Lago, L., Rodríguez Borlado, A.I., Comas, I., Herranz, M., Ruiz-Serrano, M.J., Bouza, E. & García-de-Viedma, D. (2016). Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection. International Journal of Medical Microbiology, 306(6), 401-405. 10.1016/j.ijmm.2016.05.007 |
| Doi | 10.1016/j.ijmm.2016.05.007 |
| Publication Date | Sep 2016 |
| Publication Type | Article |
| Researcher | Iñaki Comas Espadas |
| Ontology | Population genomics |
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