Iñaki Comas Espadas
Biography
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Head of the Tuberculosis Genomics Unit. I did my PhD in the University of Valencia on Evolutionary Genomics of Proteobacteria. In 2008, I moved to Dr. Sebastien Gagneux laboratory in the National Institute for Medical Research in London. We were among the first to use NGS in large scale to address issues related with host-pathogen interaction, evolution and drug resistance. In 2012 I returned to Spain with a Marie Curie and later a Ramón y Cajal and established a new line of research in tuberculosis. In 2016 I started a new position as Científico Titular at the Instituto de Biomedicina de Valencia. Current funding includes ERC Starting Grant, Ministerio de Ciencia Retos, Explora, Red de Excelencia y Equipamiento and Generalitat Valenciana Consolidables. |
Profile
| Institution | IBV |
| Position | Científico Titular |
| Home page | https://www.ibv.csic.es/en/directory/inaki-comas-en/ |
| Contact email | icomas@ibv.csic.es |
| ORCID | 0000-0001-5504-9408 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | |
| BCB Services |
Research
Research topics
Research lines
- Evolution of the Mycobacterium tuberculosis complex
- Genomic epidemiology of M. tuberculosis
- Genomic information in eHealth systems
- NGS in clinical microbiology
- Respiratory microbiome
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Projects, networks, transfer & teaching
Funded projects 5
- Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication
- Reconnecting transmission to global tuberculosis control by mapping pathogen transmission events to host infection status
- PREDICIENDO GENOTIPOS EXITOSOS DE MYCOBACTERIUM TUBERCULOSIS COMBINANDO GENÓMICA DE POBLACIONES, APROXIMACIONES FUNCIONALES Y MODELOS DE INFECCIÓN
- EXPLOTANDO LA INFORMACIÓN GENÓMICA DEL PATÓGENO PARA IDENTIFICAR NUEVOS DETERMINANTES DEL ÉXITO O FRACASO DEL TRATAMIENTO EN TUBERCULOSIS
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Publications 139 entries
- Deep sequencing reveals subpopulation dynamics associated with treatment failure in a rare non-tuberculous mycobacterial infection Preprint · 12 Aug 2026
- Complete genomes reveal a refined map of Mycobacterium tuberculosis genetic diversity across evolutionary scales Article · 6 Jun 2026
- Intravesical mycobacteria reshape bladder and gut microbiota in a murine bladder cancer model Article · 25 May 2026
- Paired wastewater and clinical genomics across metropolitan and hospital catchments reveals SARS-CoV-2 relevant mutations Preprint · 6 Apr 2026
- Population structure and spatial distribution of Mycobacterium tuberculosis complex in Catalonia Article · 20 Mar 2026
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- Stringent proteogenomic discovery of novel small proteins in Mycobacterium tuberculosis clinical reference strains Preprint · 27 Jan 2026
- Increasing clinical and public health role of Mycobacterium tuberculosis genomics Article · Jan 2026
- Genomic determinants of antibiotic resistance for Helicobacter pylori treatment: a retrospective phenotypic and genotypic observational study Article · Jan 2026
- Dynamics of Xpert MTB/RIF Ultra results in follow-up sputum samples during the first month of TB treatment Article · 31 Oct 2025
- Circulation of SARS-CoV-2 and Co-Infection with Plasmodium falciparum in Equatorial Guinea Article · 10 Sep 2025
- UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis of Mycobacterium tuberculosis Preprint · 23 Jul 2025
- The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity Article · 6 May 2025
- Gene conversion and duplication contribute to genetic variation in an outbreak of Mycobacterium tuberculosis Article · 1 May 2025
- Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study Article · Jan 2025
- Genetic diversity within diagnostic sputum samples is mirrored in the culture of Mycobacterium tuberculosis across different settings Article · 5 Sep 2024
- Comunicaciones orales rápidas/Comunicações orais rápidas Article · Sep 2024
- Quantitative drug susceptibility testing for Mycobacterium tuberculosis using unassembled sequencing data and machine learning Article · 5 Aug 2024
- Dispersal history of SARS‐CoV‐2 in Galicia, Spain Article · 28 Jun 2024
- Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein Preprint · 24 Jan 2024
- Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis Article · Jan 2024
- Signatures of transmission in within-host M. tuberculosis variation Preprint · 29 Dec 2023
- Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique Article · 4 Dec 2023
- VIPERA: Viral Intra-Patient Evolution Reporting and Analysis Preprint · 25 Oct 2023
- Wastewater monitoring of a community COVID-19 outbreak in a Spanish municipality Article · 28 Aug 2023
- Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex Article · 12 May 2023
- Deciphering the Tangible Spatio-Temporal Spread of a 25-Year Tuberculosis Outbreak Boosted by Social Determinants Article · 13 Apr 2023
- Epidemiological cluster identification using multiple data sources: an approach using logistic regression Article · 3 Mar 2023
- Evaluation of two different concentration methods for surveillance of human viruses in sewage and their effects on SARS-CoV-2 sequencing Article · Mar 2023
- Cumulative incidence of SARS‐CoV‐2 infection in the general population of the Valencian Community (Spain) after the surge of the Omicron BA.1 variant Article · 11 Nov 2022
- Prevalence of SARS-CoV-2 and co-occurrence/co-infection with malaria during the first wave of the pandemic (the Burkina Faso case) Preprint · 20 Sep 2022
- Phenogenomics of Mycobacterium abscessus Article · 25 Aug 2022
- Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics Article · 26 Jul 2022
- Whole genome sequencing analysis to evaluate the influence of T2DM on polymorphisms associated with drug resistance in M. tuberculosis Article · 24 Jun 2022
- SARS-CoV-2 adaptive immunity in nursing home residents up to eight months after two doses of the Comirnaty® COVID-19 vaccine Article · Jun 2022
- SARS‐CoV‐2 Omicron BA.1 variant breakthrough infections in nursing home residents after an homologous third dose of the Comirnaty® COVID‐19 vaccine: Looking for correlates of protection Article · 25 May 2022
- SARS‐CoV‐2 Delta‐variant breakthrough infections in nursing home residents at midterm after Comirnaty® COVID‐19 vaccination Article · 27 Apr 2022
- Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment Article · Apr 2022
- SNPs in Genes Related to DNA Damage Repair in Mycobacterium Tuberculosis: Their Association with Type 2 Diabetes Mellitus and Drug Resistance Article · 29 Mar 2022
- Severe Acute Respiratory Syndrome Coronavirus 2 Adaptive Immunity in Nursing Home Residents Following a Third Dose of the Comirnaty Coronavirus Disease 2019 Vaccine Article · 21 Mar 2022
- Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents Article · Feb 2022
- A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands Article · 12 Jan 2022
- Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain Article · Jan 2022
- The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: the case of the spike A222V mutation Preprint · 7 Dec 2021
- Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak Article · 25 Aug 2021
- The Sputum Microbiome in Pulmonary Tuberculosis and Its Association With Disease Manifestations: A Cross-Sectional Study Article · 20 Aug 2021
- Host Genetic Analysis Should Be Mandatory for Proper Classification of COVID-19 Reinfections Article · 3 Aug 2021
- Different Within-Host Viral Evolution Dynamics in Severely Immunosuppressed Cases with Persistent SARS-CoV-2 Article · 13 Jul 2021
- Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis Strains From the Same Transmission Cluster Article · 11 Jun 2021
- Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection Article · 9 Jun 2021
- Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections Article · 11 May 2021
- Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim Article · 29 Mar 2021
- Epidemiological, clinical and genomic snapshot of the first 100 B.1.1.7 SARS-CoV-2 cases in Madrid Article · 24 Mar 2021
- SplitStrains, a tool to identify and separate mixed Mycobacterium tuberculosis infections from WGS data Article · 24 Mar 2021
- Whole-genome sequencing for TB source investigations: principles of ethical precision public health Article · 1 Mar 2021
- Re: Testosterone Breakthrough Rates during Androgen Deprivation Therapy for Castration Sensitive Prostate Cancer Article · Feb 2021
- Whole genomic sequencing based genotyping reveals a specific X3 sublineage restricted to Mexico and related with multidrug resistance Article · 21 Jan 2021
- Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020 Preprint · 28 Oct 2020
- Whole-genome sequencing of Mycobacterium tuberculosis directly from clinical samples for high-resolution genomic epidemiology and drug resistance surveillance: an observational study Article · Aug 2020
- Characterization of Polymorphisms Associated with Multidrug-Resistant Tuberculosis by Whole Genomic Sequencing: A Preliminary Report from Mexico Article · 1 Jul 2020
- Serum Luteinizing Hormone Testing Can Identify Optimal Medical Castration Article · Jul 2020
- Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments Article · 29 May 2020
- GenomegaMap: Within-Species Genome-Wide dN/dS Estimation from over 10,000 Genomes Article · 13 Mar 2020
- Contaminant DNA in bacterial sequencing experiments is a major source of false genetic variability Article · 2 Mar 2020
- Author Correction: Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase Article · 21 Feb 2020
- Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events Article · 1 Jan 2020
- Uso de las tecnologías de secuenciación masiva para el diagnóstico y epidemiología de enfermedades infecciosas Article · Jan 2020
- Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code Article · 2020
- Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe Article · 2 Dec 2019
- High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain Article · 31 Oct 2019
- Development and application of affordable SNP typing approaches to genotype Mycobacterium tuberculosis complex strains in low and high burden countries Article · 25 Oct 2019
- Influence of Gut Microbiota on Progression to Tuberculosis Generated by High Fat Diet-Induced Obesity in C3HeB/FeJ Mice Article · 18 Oct 2019
- Tuberculosis of the elbow: A rare form of presentation of extrapulmonary tuberculosis Article · Oct 2019
- The Future of TB Resistance Diagnosis: The Essentials on Whole Genome Sequencing and Rapid Testing Methods Article · Aug 2019
- Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues Article · 17 Jun 2019
- Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico Article · 5 Jun 2019
- Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics Preprint · 6 Mar 2019
- DeepAMR for predicting co-occurrent resistance of Mycobacterium tuberculosis Article · 28 Jan 2019
- Application of machine learning techniques to tuberculosis drug resistance analysis Article · 21 Nov 2018
- China’s tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis Article · 5 Nov 2018
- Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing Article · 11 Oct 2018
- TB Transmission: Closing the Gaps Article · Aug 2018
- Whole-genome sequence analysis of the Mycobacterium avium complex and proposal of the transfer of Mycobacterium yongonense to Mycobacterium intracellulare subsp. yongonense subsp. nov. Article · 1 Jun 2018
- Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex Preprint · 4 May 2018
- The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes Article · 9 Jan 2018
- A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis Article · Dec 2017
- In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution Article · 24 Apr 2017
- The effect size of type 2 diabetes mellitus on tuberculosis drug resistance and adverse treatment outcomes Article · Mar 2017
- A novel strategy based on genomics and specific PCR reveals how a multidrug-resistant Mycobacterium tuberculosis strain became prevalent in Equatorial Guinea 15 years after its emergence Article · Feb 2017
- Genomic Epidemiology of Tuberculosis Book / chapter · 2017
- The Evolution of Antibiotic Resistance Book / chapter · 2017
- Gene expression models based on a reference laboratory strain are bad predictors of Mycobacterium tuberculosis complex transcriptional diversity Preprint · 2 Dec 2016
- Urgent Implementation in a Hospital Setting of a Strategy To Rule Out Secondary Cases Caused by Imported Extensively Drug-Resistant Mycobacterium tuberculosis Strains at Diagnosis Article · Dec 2016
- New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles Article · 28 Nov 2016
- Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages Article · 31 Oct 2016
- Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection Article · Sep 2016
- Secuenciación masiva para el diagnóstico y la epidemiología de tuberculosis Article · Jul 2016
- Draft Genome Sequence of Mycobacterium brumae ATCC 51384 Article · 28 Apr 2016
- Ultrafast Assessment of the Presence of a High-Risk Mycobacterium tuberculosis Strain in a Population Article · Mar 2016
- Legionella effectors reflect strength in diversity Article · 27 Jan 2016
- Genomic Analysis of Bacterial Outbreaks Book / chapter · 2016
- Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa Article · Dec 2015
- Persistent Infection by a Mycobacterium tuberculosis Strain That Was Theorized To Have Advantageous Properties, as It Was Responsible for a Massive Outbreak Article · Nov 2015
- Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese Article · 15 Jun 2015
- Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis Article · 4 Mar 2015
- Fast and low-cost decentralized surveillance of transmission of tuberculosis based on strain-specific PCRs tailored from whole genome sequencing data: a pilot study Article · Mar 2015
- Draft Genome Sequences of Mycobacterium setense Type Strain DSM-45070 and the Nonpathogenic Strain Manresensis, Isolated from the Bank of the Cardener River in Manresa, Catalonia, Spain Article · 26 Feb 2015
- Estudios de epidemiología molecular en población inmigrante en España Article · Dec 2014
- Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates Article · 5 Oct 2014
- Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis Article · 20 Aug 2014
- Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay Article · Jul 2014
- Vacunas y evolución: ¿Por qué es importante entender la diversidad genética de los patógenos? Article · 1 Jun 2014
- Comment on: Characterization of the embB gene in Mycobacterium tuberculosis isolates from Barcelona and rapid detection of main mutations related to ethambutol resistance using a low-density DNA array Article · 20 Apr 2014
- Evaluation of Customised Lineage-Specific Sets of MIRU-VNTR Loci for Genotyping Mycobacterium tuberculosis Complex Isolates in Ghana Article · 25 Mar 2014
- Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis Article · Jan 2014
- Mapping of Genotype–Phenotype Diversity among Clinical Isolates of Mycobacterium tuberculosis by Sequence-Based Transcriptional Profiling Article · 16 Sep 2013
- Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans Article · 1 Sep 2013
- Whole Genome Sequencing Analysis of Intrapatient Microevolution in Mycobacterium tuberculosis: Potential Impact on the Inference of Tuberculosis Transmission Article · 14 Aug 2013
- Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee Article · Jun 2013
- Mycobacterial Lineages Causing Pulmonary and Extrapulmonary Tuberculosis, Ethiopia Article · Mar 2013
- Evidence for Diversifying Selection in a Set of Mycobacterium tuberculosis Genes in Response to Antibiotic- and Nonantibiotic-Related Pressure Article · 28 Feb 2013
- Two New Rapid SNP-Typing Methods for Classifying Mycobacterium tuberculosis Complex into the Main Phylogenetic Lineages Article · 20 Jul 2012
- Long-Range Transcriptional Control of an Operon Necessary for Virulence-Critical ESX-1 Secretion in Mycobacterium tuberculosis Article · May 2012
- The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-Specific Locus and Genome Erosion Common to the M. tuberculosis Complex Article · 28 Feb 2012
- Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes Article · 18 Dec 2011
- Sequence-Based Analysis Uncovers an Abundance of Non-Coding RNA in the Total Transcriptome of Mycobacterium tuberculosis Article · 3 Nov 2011
- A role for systems epidemiology in tuberculosis research Article · Oct 2011
- Human Macrophage Responses to Clinical Isolates from the Mycobacterium tuberculosis Complex Discriminate between Ancient and Modern Lineages Article · 3 Mar 2011
- Quantifying Nonvertical Inheritance in the Evolution of Legionella pneumophila Article · 20 Oct 2010
- Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved Article · 23 May 2010
- Evolutionary Trajectories of Beta-Lactamase CTX-M-1 Cluster Enzymes: Predicting Antibiotic Resistance Article · 22 Jan 2010
- Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies Article · 12 Nov 2009
- The Past and Future of Tuberculosis Research Article · 26 Oct 2009
- Evolution of Snake Venom Disintegrins by Positive Darwinian Selection Article · 21 Aug 2008
- Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context Article · 16 May 2008
- Phylogenetic signal and functional categories in Proteobacteria genomes Article · 8 Feb 2007
- From Phylogenetics to Phylogenomics: The Evolutionary Relationships of Insect Endosymbiotic γ-Proteobacteria as a Test Case Article · 1 Feb 2007
- The Evolutionary Origin of Xanthomonadales Genomes and the Nature of the Horizontal Gene Transfer Process Article · 1 Aug 2006
- Horizontal Gene Transfer in the Molecular Evolution of Mannose PTS Transporters Article · 27 Apr 2005
- Validating viral quasispecies with digital organisms: a re-examination of the critical mutation rate Article · 15 Jan 2005
