Detalle de: Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

(Cell Reports 5, 1121–1131; November 21, 2013) In the originally published version of this article, the data in Table S3 were incorrectly sorted. The article has been updated with a new version of the table, and the data have been sorted correctly. The authors regret this error and any confusion that may have resulted. Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosisCortes et al.Cell ReportsNovember 21, 2013In BriefIn this study, Cortes, Young, and colleagues report genome-wide mapping of transcriptional start sites combined with RNA sequencing and shotgun proteomics in the human pathogen Mycobacterium tuberculosis. A striking finding is a high proportion of genes expressed in the form of leaderless transcripts lacking the Shine-Dalgarno sequence conventionally required for translation. The distribution of functional gene classes between leaderless and Shine-Dalgarno transcriptomes suggests that changes in the specificity of translation may play a role in bacterial adaptation during infection. Full-Text PDF Open Access