Detalle de: Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB 2 Receptor**
| Title | Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB 2 Receptor** |
| Abstract |
Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB 2 receptor. These compounds selectively target CB 2 versus CB 1 receptors. Their binding mode was studied by molecular dynamic simulations and site‐directed mutagenesis. |
| Apa Reference | Morales, P., Navarro, G., Gómez‐Autet, M., Redondo, L., Fernández‐Ruiz, J., Pérez‐Benito, L., Cordomí, A., Pardo, L., Franco, R. & Jagerovic, N. (2020). Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB 2 Receptor**. Chemistry – A European Journal, 26(68), 15839-15842. 10.1002/chem.202003389 |
| Doi | 10.1002/chem.202003389 |
| Publication Date | 9 Nov 2020 |
| Publication Type | Article |
| Researcher | Paula Morales |
| Ontology | Computational models and simulations, Mutation Analysis and design, Molecular Interactions/Docking |
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