Paula Morales
Profile
| Institution | IQM |
| Position | Tenured scientist |
| Home page | https://www.linkedin.com/in/paula-morales-8456031aa/ |
| Contact email | paula.morales@iqm.csic.es |
| ORCID | 0000-0002-6209-8600 |
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Research
Research topics
None
Research lines
- New strategies to modulate the canonical cannabinoid receptors
- Identification of new ligands for orphan G protein-coupled receptors (GPR12, GPR18, GPR55...)
- Structural determinants of cannabinoid activity
- Indirect modulation of the endocannabinoid system (PPAR, AMPK...)
- Cannabinoid-based therapeutic approaches for cancer, inflammation and neurodegenerative diseases
Publications 70 entries
- PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain Article · Nov 2026
- Discovery and pharmacological evaluation of a novel series of chromenopyrazole-based GPR55 modulators in an androgen-driven model of female metabolic dysfunction Article · Aug 2026
- Computational Studies toward the Identification of CB2R-M1R Dual Modulators Article · 19 Feb 2026
- Structural and functional dissection of the WH2 / DAD motif of INF2 , a formin linked to human inherited degenerative disorders Article · 24 Sep 2025
- Investigation in the CB1 and CB2 receptor binding profile and intrinsic activity of (−) and (+)-enantiomers of some naturally occurring phytocannabinoids or synthetic derivatives Article · Aug 2025
View all (65 more)
- Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling Article · Oct 2024
- Progress on the development of Class A GPCR‐biased ligands Article · 11 Sep 2024
- The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls Article · 21 Mar 2024
- Activation of CB2R by synthetic CB2R agonist, PM289, improves brain endothelial barrier properties, decreases inflammatory response and enhances endothelial repair Article · 16 Oct 2023
- Editorial: New approaches for the discovery of GPCR ligands Article · 21 Aug 2023
- Linking the G-protein-coupled receptor 55 (GPR55) to the cannabinoid receptors (CB1 and CB2): A new narrative Book / chapter · 2023
- Editorial: Cannabinoids as potential treatment for neurological diseases Article · 20 Dec 2022
- Viewpoint on the Second Transatlantic GPCR Symposium for Early Career Investigators Article · 16 Dec 2022
- Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure–Activity Relationship Article · 2 Dec 2022
- The oncogenic lysophosphatidylinositol (LPI)/GPR55 signaling Article · Jul 2022
- Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators Article · 25 Feb 2022
- The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors Article · 16 Feb 2022
- Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis Article · 16 Dec 2021
- Cannabinoid-based Anti-cancer Strategies: Slowly Approaching the Bedside Book / chapter · 8 Aug 2021
- Relevance of Peroxisome Proliferator Activated Receptors in Multitarget Paradigm Associated with the Endocannabinoid System Article · 20 Jan 2021
- Synthetic and Natural Derivatives of Cannabidiol Book / chapter · 2021
- Emerging Roles of Cannabinoids and Synthetic Cannabinoids in Clinical Experimental Models Book / chapter · 18 Dec 2020
- Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB 2 Receptor** Article · 9 Nov 2020
- Ligand-based drug design approaches for the identification of novel GPR55 modulators Conference paper · 6 Nov 2020
- Exploring the orphan GPCR GPR18 through novel synthetic cannabidiol derivatives Conference paper · 6 Nov 2020
- Structural Insights into β-arrestin/CB1 Receptor Interaction: NMR and CD Studies on Model Peptides Article · 30 Oct 2020
- Therapeutic Exploitation of GPR18: Beyond the Cannabinoids? Article · 11 Sep 2020
- Novel approaches and current challenges with targeting the endocannabinoid system Article · 27 Apr 2020
- GPR6 Structural Insights: Homology Model Construction and Docking Studies Article · 7 Feb 2020
- Constructing GPR6 Homology Model, Docking Studies and Drug Design Article · Feb 2020
- Chapter 5. Natural and Synthetic Cannabinoids Targeting Non-CB1, Non-CB2 G Protein-coupled Receptors Book / chapter · 2020
- Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding Article · 13 Sep 2019
- Design, Synthesis, and Pharmacological Evaluation of Novel Quinolone Aryl Sulfonamide Derivatives as Potent GPR55 Antagonists Conference paper · 2 Sep 2019
- Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage Article · Jul 2019
- Antitumor Cannabinoid Chemotypes: Structural Insights Article · 31 May 2019
- Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity Article · 9 May 2019
- CBD: A New Hope? Article · 29 Apr 2019
- Structural Insights into CB1 Receptor Biased Signaling Article · 13 Apr 2019
- Cannabinoid Ligands Targeting TRP Channels Article · 15 Jan 2019
- Design and structural characterisation of monomeric water-soluble α-helix and β-hairpin peptides: State-of-the-art Article · Jan 2019
- Emerging strategies targeting CB2 cannabinoid receptor: Biased agonism and allosterism Article · Nov 2018
- Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes Article · Nov 2018
- ( R )- N -(1-Methyl-2-hydroxyethyl)-13-( S )-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes Article · 10 Sep 2018
- Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone‐Based Cannabinoid Receptor Type 2 Ligands Article · 16 Apr 2018
- Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12 Article · 2 Jan 2018
- In Vitro Primary Screening of a Synthetic Series of Chromenoazoldiones against Trypanosoma cruzi Conference paper · 17 Oct 2017
- An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol Article · 28 Jun 2017
- Corrigendum to “Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile” [Pharmacol. Res. 110 (August 2016) (2016) 205–215] Article · Jun 2017
- New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking Article · Feb 2017
- Synthesis of a novel CB2 cannabinoid-porphyrin conjugate based on an antitumor chromenopyrazoledione Article · Jan 2017
- Methods for the Development of In Silico GPCR Models Book / chapter · 2017
- Molecular Targets of the Phytocannabinoids: A Complex Picture Book / chapter · 2017
- Exploring the Benzimidazole Ring as a Substitution for Indole in Cannabinoid Allosteric Modulators Article · Dec 2016
- Allosteric Modulators of the CB 1 Cannabinoid Receptor: A Structural Update Review Article · Dec 2016
- A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives Article · Oct 2016
- Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders Article · 13 Sep 2016
- Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile Article · Aug 2016
- Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis Article · 6 Jul 2016
- Cannabinoid receptor 2 (CB 2 ) agonists and antagonists: a patent update Article · 7 Jun 2016
- Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles Article · Jun 2016
- Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology Article · 5 Feb 2016
- Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB 2 receptor antagonists Article · Aug 2015
- Selective, Nontoxic CB 2 Cannabinoid o -Quinone with in Vivo Activity against Triple-Negative Breast Cancer Article · 20 Feb 2015
- Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results Article · Feb 2014
- Synthetic cannabinoid quinones: Preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity Article · Dec 2013
- Preparation of 2,2-dimethylchroman-4-ones from 5-alkyl-substituted resorcinols: microwave-assisted synthesis and theoretical calculations Article · 6 Nov 2013
- Description of a Bivalent Cannabinoid Ligand with Hypophagic Properties Article · Feb 2013
- Tautomerism of hydroxychromenopyrazoles Article · May 2012
- Chromenopyrazoles: Non‐psychoactive and Selective CB 1 Cannabinoid Agonists with Peripheral Antinociceptive Properties Article · 2 Feb 2012
- Determination of the absolute configuration of 1,3,5-triphenyl-4,5-dihydropyrazole enantiomers by a combination of VCD, ECD measurements, and theoretical calculations Article · May 2011