Detalle de: Preparation of 2,2-dimethylchroman-4-ones from 5-alkyl-substituted resorcinols: microwave-assisted synthesis and theoretical calculations
| Title | Preparation of 2,2-dimethylchroman-4-ones from 5-alkyl-substituted resorcinols: microwave-assisted synthesis and theoretical calculations |
| Abstract |
The influence of different 5-alkyl-substituted resorcinols on the formation of 2,2-dimethylchroman-4-ones is examined experimentally and theoretically.Structures are fully assigned by means of experimental and theoretical 13 C and 1 H NMR chemical shifts.Based on experimental and theoretical calculations of Friedel-Crafts acylation, it is possible to explain the formation of 2,2-dimethyl-5-hydroxychroman-4-ones and/or 2,2-dimethyl-7-hydroxychroman-4-ones.Evaluation of their biological activity as cannabinoid receptor ligands is also reported. |
| Apa Reference | Morales, P., Azofra, L.M., Cumella, J., Hernandez-Folgado, L., Roldán, M., Alkorta, I. & Jagerovic, N. (2013). Preparation of 2,2-dimethylchroman-4-ones from 5-alkyl-substituted resorcinols: microwave-assisted synthesis and theoretical calculations. Arkivoc, 2014(2), 319-332. 10.3998/ark.5550190.p008.246 |
| Doi | 10.3998/ark.5550190.p008.246 |
| Publication Date | 6 Nov 2013 |
| Publication Type | Article |
| Researcher | Paula Morales |
| Ontology | Molecular Interactions/Docking |
| Research Groups | |
| Tools |