Detalle de: Effect of probiotics in prevention of atopic dermatitis is dependent on the intrinsic microbiota at early infancy

Although a link between probiotic intervention and reduction in atopic disease has been 17 documented, no consistent associations with microbiota has yet been established. Here we 18 have conducted an extensive analysis of the microbiota from more than 250 mother child 19 pairs from a probiotic intervention cohort, where we previously have shown 40 % reduction in 20 atopic dermatitis. Within the probiotic intervention group at the age of 10 days we found that 21 the atopic children had a deviating microbiota (p = 0.028, BH-FDR corrected Kruskal Wallis) 22 with high levels (> 10 %) of a bacterium related to Bifidobacterium dentium (p=0.039, BH- 23 FDR corrected Chi-square). Based on these findings, we propose a model with two groups of 24 children where the group responding to probiotic intervention, has gut microbiota related to 25 that of non-atopic children; while the non-responding group has a divergent microbiota at