Detalle de: Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection
| Title | Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection |
| Abstract |
Despite the high virological response rates achieved with current directly acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 2% to 5% of treated patients do not achieve a sustained viral response. The identification of amino acid substitutions associated with treatment failure requires analytical designs, such as subtype-specific ultradeep sequencing (UDS) methods, for HCV characterization and patient management. Using this procedure, we have identified six highly represented amino acid substitutions (HRSs) in NS5A and NS5B of HCV, which are not bona fide resistance-associated substitutions (RAS), from 220 patients who failed therapy. |
| Apa Reference | Soria, M.E., García-Crespo, C., Martínez-González, B., Vázquez-Sirvent, L., Lobo-Vega, R., de Ávila, A.I., Gallego, I., Chen, Q., García-Cehic, D., Llorens-Revull, M., Briones, C., Gómez, J., Ferrer-Orta, C., Verdaguer, N., Gregori, J., Rodríguez-Frías, F., Buti, M., Esteban, J.I., Domingo, E., Quer, J. & Perales, C. (2020). Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection. Journal of Clinical Microbiology, 58(12). 10.1128/JCM.01985-20 |
| Doi | 10.1128/JCM.01985-20 |
| Publication Date | 18 Nov 2020 |
| Publication Type | Article |
| Researcher | Carlos Briones Llorente |
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