Carlos Briones Llorente
Biography
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Carlos Briones holds a degree in Chemistry (specialising in Biochemistry and Molecular Biology) and a PhD in Science, with a thesis carried out at the Centro de Biología Molecular Severo Ochoa (CSIC-UAM). He is a tenured CSIC researcher and coordinator of the Molecular Evolution, RNA World and Biosensors Group at the Centro de Astrobiología (CSIC-INTA). His research lines are: (i) the origin and early evolution of life (experimental and theoretical approaches to the RNA world model and to prebiotic systems chemistry); (ii) in vitro evolution of nucleic acids (RNA and DNA aptamers against different molecules and biomarkers); (iii) genetics of RNA viruses (dynamics of viral quasispecies and sequence/structure/function relationships in their genomic RNA); and (iv) development of biosensors (based on aptamers, DNA and protein microarrays, and nanobiosensors). He collaborates in interdisciplinary projects analysing microbial biodiversity in extreme environments (MARTE and IPBSL) and identifying molecular precursors of the RNA world in the interstellar medium. He has participated in 25 competitive research projects, as principal investigator in 10 of them. He has co-authored more than 120 articles, over 80 of them in journals indexed in the Web of Science (h-index 30), and is co-inventor of 10 patents and utility models. He is a member of the Executive Committees of the European Astrobiology Institute (EAI) and of the María de Maeztu Unit of Excellence – CAB, and a board member of the Spanish Society for Virology (SEV). Since 2016 he has been Scientific Secretary of the International School of Astrobiology "Josep Comas i Solà" (CAB-UIMP-NASA). He coordinates the research challenge "The origins of life: from chemistry to biology", within the strategic theme "Origins, (co)evolution, diversity and synthesis of life" of the CSIC 2030 White Papers, and the CSIC Interdisciplinary Thematic Platform (PTI) "Origin of life: evolution towards the emergence of biochemical functions". He also has extensive experience in science outreach and communication as a speaker, activity coordinator and author of articles and books, including Orígenes. El Universo, la vida, los humanos (Ed. Crítica, 2015) and ¿Estamos solos? En busca de otras vidas en el Cosmos (Ed. Crítica, 2020). |
Profile
| Institution | CAB |
| Position | Research Scientist CSIC |
| Home page | https://cab.inta-csic.es/personal/carlos-briones-llorente/ |
| Contact email | cbriones@cab.inta-csic.es |
| ORCID | 0000-0003-2213-8353 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | |
| BCB Services |
Research
Research topics
None
Research lines
Publications 88 entries
- A mathematical model for fitness effects on viral persistence Preprint · 16 Sep 2026
- Author Correction: Detection of a four-carbon sugar in interstellar space Article · 14 Aug 2026
- In Vitro -Selected DNA Aptamers Enable Detection of the Ancestral Peptide 3C8Y in [FeFe]-Hydrogenase CpI and in Metal-Rich, Acidic Environments: Implications for Astrobiology Article · 11 Aug 2026
- Detection of a four-carbon sugar in interstellar space Article · 13 Jul 2026
- Ultrasensitive graphene FET aptasensor for direct attomolar detection of glutamate in human clinical samples Preprint · 7 Nov 2025
View all (83 more)
- Polymerization and replication of primordial RNA induced by clay-water interface dynamics Article · 7 Aug 2025
- Adapting the rhizome concept to an extended definition of viral quasispecies and the implications for molecular evolution Article · 2 Aug 2024
- Did organs precede organisms in the origin of life? Article · 2024
- Natural languages and RNA virus evolution Article · 20 Nov 2023
- Archaeological approaches to RNA virus evolution Article · 11 Oct 2023
- Viruses as archaeological tools for uncovering ancient molecular relationships Article · 6 Oct 2023
- Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus Article · 18 Jul 2023
- Attomolar detection of hepatitis C virus core protein powered by molecular antenna-like effect in a graphene field-effect aptasensor Article · Feb 2023
- Coupled C, H, N, S and Fe biogeochemical cycles operating in the continental deep subsurface of the Iberian Pyrite Belt Article · 9 Dec 2022
- In vitro Selection of High Affinity DNA and RNA Aptamers that Detect Hepatitis C Virus Core Protein of Genotypes 1 to 4 and Inhibit Virus Production in Cell Culture Article · Apr 2022
- Discovery in space of ethanolamine, the simplest phospholipid head group Article · 24 May 2021
- Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C Virus Article · 3 Apr 2021
- Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection Article · 18 Nov 2020
- The Complex Molecules Detector (CMOLD): A Fluidic-Based Instrument Suite to Search for (Bio)chemical Complexity on Mars and Icy Moons Article · Sep 2020
- Prebiotic Precursors of the Primordial RNA World in Space: Detection of NH 2 OH Article · 1 Aug 2020
- A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbations Article · Aug 2020
- Dissimilar conservation pattern in hepatitis C virus mutant spectra, consensus sequences, and data banks Preprint · 3 Jul 2020
- Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment Article · 28 Feb 2020
- The archaeology of coding RNA Article · 25 Jun 2019
- A Combined ELONA-(RT)qPCR Approach for Characterizing DNA and RNA Aptamers Selected against PCBP-2 Article · 28 Mar 2019
- Versatile Graphene-Based Platform for Robust Nanobiohybrid Interfaces Article · 14 Feb 2019
- Direct visualization of the native structure of viroid RNAs at single-molecule resolution by atomic force microscopy Article · 8 Feb 2019
- Morphology Clustering Software for AFM Images, Based on Particle Isolation and Artificial Neural Networks Article · 2019
- Experimental conditions affecting the kinetics of aqueous HCN polymerization as revealed by UV–vis spectroscopy Article · Feb 2018
- Chemical roots of biological evolution: the origins of life as a process of development of autonomous functional systems Article · Apr 2017
- Correction for Quer at al., High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods Article · Jul 2016
- High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods Article · Jan 2015
- A magnesium-induced RNA conformational switch at the internal ribosome entry site of hepatitis C virus genome visualized by atomic force microscopy Article · 15 Dec 2014
- A novel representation of genomic sequences for taxonomic clustering and visualization by means of self-organizing maps Article · 24 Oct 2014
- Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies Article · 1 Sep 2014
- Structural modifications of gold thin films produced by thiol-derivatized single-stranded DNA immobilization Article · 17 Jan 2014
- Deep subsurface sulfate reduction and methanogenesis in the Iberian Pyrite Belt revealed through geochemistry and molecular biomarkers Article · 16 Nov 2013
- Prebiotic Systems Chemistry: New Perspectives for the Origins of Life Article · 31 Oct 2013
- Iberian Pyrite Belt Subsurface Life (IPBSL), a Drilling Project of Biohydrometallurgical Interest Article · Oct 2013
- End-to-end crosstalk within the hepatitis C virus genome mediates the conformational switch of the 3′X-tail region Article · 17 Sep 2013
- EMERGENCE AND SELECTION OF BIOMODULES: STEPS IN THE ASSEMBLY OF A PROTOCELL Book / chapter · 12 Dec 2012
- The folding of the hepatitis C virus internal ribosome entry site depends on the 3′-end of the viral genome Article · 12 Oct 2012
- Applications of peptide nucleic acids (PNAs) and locked nucleic acids (LNAs) in biosensor development Article · 2 Feb 2012
- Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation Article · 8 Jul 2011
- Structural analysis provides insights into the modular organization of picornavirus IRES Article · Jan 2011
- The metavirome of a hypersaline environment Article · Nov 2010
- Populations of RNA Molecules as Computational Model for Evolution Book / chapter · 2010
- The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers Article · 24 Mar 2009
- Nucleic acid interactions with pyrite surfaces Article · Sep 2008
- Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection Article · 17 Jul 2008
- Silicon Surface Nanostructuring for Covalent Immobilization of Biomolecules Article · 1 Jun 2008
- On the structural repertoire of pools of short, random RNA sequences Article · Jun 2008
- Synthesis of cobalt ferrite core/metallic shell nanoparticles for the development of a specific PNA/DNA biosensor Article · May 2008
- Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films Article · 20 Apr 2008
- Characterization of minority subpopulations in the mutant spectrum of HIV-1 quasispecies by successive specific amplifications Article · Nov 2007
- Do peptide nucleic acids form self-assembled monolayers on pyrite surfaces? Article · Sep 2007
- Collective properties of evolving molecular quasispecies Article · 9 Jul 2007
- A DNA biosensor based on peptide nucleic acids on gold surfaces Article · Apr 2007
- Minority memory genomes can influence the evolution of HIV-1 quasispecies in vivo Article · Dec 2006
- Modular evolution and increase of functional complexity in replicating RNA molecules Article · 14 Nov 2006
- The interaction of peptide nucleic acids (PNAs) with mineral surfaces: Self-assembly processes in the abiotic–biotic transition? Article · Aug 2006
- Nucleic Acids and Their Analogs as Nanomaterials for Biosensor Development Article · Aug 2006
- STEC-EPEC Oligonucleotide Microarray: A New Tool for Typing Genetic Variants of the LEE Pathogenicity Island of Human and Animal Shiga Toxin–Producing Escherichia coli (STEC) and Enteropathogenic E. coli (EPEC) Strains Article · 1 Feb 2006
- Self-Assembled Monolayers of Peptide Nucleic Acids on Gold Surfaces: A Spectroscopic Study Article · 16 Sep 2005
- Ordered SAMS of peptide nucleic acids on surfaces with DNA recognition capability Article · 23 Aug 2005
- Instrument development to search for biomarkers on mars: Terrestrial acidophile, iron-powered chemolithoautotrophic communities as model systems Article · Jun 2005
- Structural and functional characterization of self-assembled monolayers of peptide nucleic acids and its interaction with complementary DNA Article · Mar 2005
- Reconstructing evolutionary relationships from functional data: a consistent classification of organisms based on translation inhibition response Article · Feb 2005
- Ordered Self-Assembled Monolayers of Peptide Nucleic Acids with DNA Recognition Capability Article · 11 Nov 2004
- Structural analysis of hepatitis C RNA genome using DNA microarrays Article · 21 Jun 2004
- Memory in Retroviral Quasispecies: Experimental Evidence and Theoretical Model for Human Immunodeficiency Virus Article · Aug 2003
- Duration and fitness dependence of quasispecies memory Article · Jan 2002
- Primary Genotypic and Phenotypic HIV-1 Drug Resistance in Recent Seroconverters in Madrid Article · Feb 2001
- Prevalence and Genetic Heterogeneity of the Reverse Transcriptase T69S-S-X Insertion in Pretreated HIV-Infected Patients Article · 2001
- Conformational changes induced in the Saccharomyces cerevisiae GTPase-associated rRNA by ribosomal stalk components and a translocation inhibitor Article · 15 Nov 2000
- Role of a dipeptide insertion between codons 69 and 70 of HIV‐1 reverse transcriptase in the mechanism of AZT resistance Article · 1 Nov 2000
- Prevalence of Novel Lamivudine-Resistant Genotypes (E44D/A, V118I) in Naive and Pretreated HIV-Infected Individuals Article · Sep 2000
- Prevalence of drug-resistant HIV-1 genotypes in heavily pre-treated patients on current virological failure Article · Jul 2000
- Can Early Failure With Nevirapine Be Rescued With Efavirenz? Article · May 2000
- Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in Spain Article · Apr 2000
- Nucleotide Sequence of the 23S rRNA from Haloferax mediterranei and Phylogenetic Analysis of Halophilic Archaea Based on LSU rRNA Article · Apr 2000
- Emergence of Zidovudine Resistance in HIV-Infected Patients Receiving Stavudine Article · Mar 2000
- Dynamics of dominance of a dipeptide insertion in reverse transcriptase of HIV-1 from patients subjected to prolonged therapy Article · Jan 2000
- Hepatitis C virus genotypes in immigrants from equatorial guinea Article · 2000
- Usefulness of Genotypic Analysis of Resistance to Nucleoside Analogues in the Clinical Setting Article · 7 Jul 1999
- Introduction of HIV drug-resistance testing in clinical practice Article · Jun 1999
- The GTPase Center Protein L12 Is Required for Correct Ribosomal Stalk Assembly but Not for Saccharomyces cerevisiaeViability Article · Nov 1998
- Functional Phylogeny: the Use of the Sensitivity of Ribosomes to Protein Synthesis Inhibitors as a Tool to Study the Evolution of Organisms Article · Oct 1998
