Detalle de: Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment
| Title | Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment |
| Abstract |
The study shows that extensive replication of an RNA virus in a constant biological environment does not limit exploration of sequence space and adaptive options. There was no convergence toward a restricted set of adapted genomes. Mutational waves and mutant spectrum broadening affected infectious genomes. Therefore, profound modifications of mutant spectrum composition and consensus sequence diversification are not exclusively dependent on environmental alterations or the intervention of population bottlenecks. |
| Apa Reference | Gallego, I., Soria, M.E., García-Crespo, C., Chen, Q., Martínez-Barragán, P., Khalfaoui, S., Martínez-González, B., Sanchez-Martin, I., Palacios-Blanco, I., de Ávila, A.I., García-Cehic, D., Esteban, J.I., Gómez, J., Briones, C., Gregori, J., Quer, J., Perales, C. & Domingo, E. (2020). Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment. Journal of Virology, 94(6). 10.1128/jvi.01856-19 |
| Doi | 10.1128/jvi.01856-19 |
| Publication Date | 28 Feb 2020 |
| Publication Type | Article |
| Researcher | Carlos Briones Llorente |
| Ontology | Mutation Analysis and design |
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