Detalle de: Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1- S - and C1- O -Nucleophiles
| Title | Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1- S - and C1- O -Nucleophiles |
| Abstract |
Starting from commercially available (S)-isoserine and effectively accessible (S)-α-methylserine, enantiopure cyclic sulfamidates have been prepared as chiral building blocks for the synthesis of various S- and O-glycosylated amino acid derivatives, including unnatural variants of the Tn antigen, through highly chemo-, regio-, and stereoselective nucleophilic ring-opening reactions with carbohydrate C1-S- and C1-O-nucleophiles. |
| Apa Reference | Tovillas, P., García, I., Oroz, P., Mazo, N., Avenoza, A., Corzana, F., Jiménez-Osés, G., Busto, J.H. & Peregrina, J.M. (2018). Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1- S - and C1- O -Nucleophiles. The Journal of Organic Chemistry, 83(9), 4973-4980. 10.1021/acs.joc.7b03225 |
| Doi | 10.1021/acs.joc.7b03225 |
| Publication Date | 11 Apr 2018 |
| Publication Type | Article |
| Researcher | Gonzalo Jiménez-Osés |
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