Detalle de: Insights into the Geometrical Features Underlying β‐ O ‐GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone
| Title | Insights into the Geometrical Features Underlying β‐ O ‐GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone |
| Abstract |
Water pockets at key sites as well as specific hydrogen bonds modulate sugar–peptide interactions in β-N-acetyl-D-glucosamine (β-O-GlcNAc) glycopeptides (see picture). It is likely that these solvent pockets have important biological implications, providing the required presentation of the GlcNAc moieties to interact with their biological receptors. |
| Apa Reference | Fernández‐Tejada, A., Corzana, F., Busto, J.H., Jiménez‐Osés, G., Jiménez‐Barbero, J., Avenoza, A. & Peregrina, J.M. (2009). Insights into the Geometrical Features Underlying β‐ O ‐GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone. Chemistry – A European Journal, 15(30), 7297-7301. 10.1002/chem.200901204 |
| Doi | 10.1002/chem.200901204 |
| Publication Date | 17 Jul 2009 |
| Publication Type | Article |
| Researcher | Gonzalo Jiménez-Osés |
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