Detalle de: Serine versus Threonine Glycosylation: The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell
| Title | Serine versus Threonine Glycosylation: The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell |
| Abstract |
Different behavior has been observed for the psi torsion angle of the glycosidic linkages of D-GalNAc-Ser and D-GalNAc-Thr motifs, allowing the carbohydrate moiety to adopt a completely different orientation. In addition, the fact that the water pockets found in alpha-D-GalNAc-Thr differ from those obtained for its serine analogue could be related to the different capability that the two model glycopeptides have to structure the surrounding water. This fact could have important biological inferences (i.e., antifreeze activity). |
| Apa Reference | Corzana, F., Busto, J.H., Jiménez-Osés, G., García de Luis, M., Asensio, J.L., Jiménez-Barbero, J., Peregrina, J.M. & Avenoza, A. (2007). Serine versus Threonine Glycosylation: The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell. Journal of the American Chemical Society, 129(30), 9458-9467. 10.1021/ja072181b |
| Doi | 10.1021/ja072181b |
| Publication Date | 7 Jul 2007 |
| Publication Type | Article |
| Researcher | Gonzalo Jiménez-Osés |
| Ontology | Sequence analysis |
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