Detalle de: Enantioselective Synthesis of S -Linked Glycosyl-β 2,2 -Amino Acid Derivatives by S N 2 Reaction with Hindered Sulfamidates
| Title | Enantioselective Synthesis of S -Linked Glycosyl-β 2,2 -Amino Acid Derivatives by S N 2 Reaction with Hindered Sulfamidates |
| Abstract |
A new type of sugar-amino acid hybrid is presented and comprises of a sugar unit (mono- or disaccharide) α- or β-linked through an S-glycosidic linkage to the α-position of an α,α-disubstituted β-amino acid unit. The synthetic strategy is based on an SN2 reaction between protected 1-thiosugars as nucleophiles and a hindered α-methylisoserine-derived sulfamidate as the chiral starting material. |
| Apa Reference | Avenoza, A., Peregrina, J.M., Busto, J.H. & Jiménez-Osés, G. (2006). Enantioselective Synthesis of S -Linked Glycosyl-β 2,2 -Amino Acid Derivatives by S N 2 Reaction with Hindered Sulfamidates. Synthesis, 2006(04), 641-644. 10.1055/s-2006-926286 |
| Doi | 10.1055/s-2006-926286 |
| Publication Date | 2006 |
| Publication Type | Article |
| Researcher | Gonzalo Jiménez-Osés |
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