Detalle de: A Convenient Enantioselective Synthesis of ( S )-α-Trifluoromethylisoserine
| Title | A Convenient Enantioselective Synthesis of ( S )-α-Trifluoromethylisoserine |
| Abstract |
[reaction: see text] This report describes two straightforward synthetic methodologies to obtain alpha-CF3-isoserine, a new alpha,alpha-disubstituted beta-amino acid, from alpha-(trifluoromethyl)acrylic acid. The routes involve the synthesis of five-membered cyclic sulfates (using sulfuryl chloride) or sulfamidates (using the Burgess reagent) from the corresponding chiral diols, which are obtained by a catalytic asymmetric dihydroxylation (AD) reaction. |
| Apa Reference | Avenoza, A., Busto, J.H., Jiménez-Osés, G. & Peregrina, J.M. (2005). A Convenient Enantioselective Synthesis of ( S )-α-Trifluoromethylisoserine. The Journal of Organic Chemistry, 70(14), 5721-5724. 10.1021/jo0505371 |
| Doi | 10.1021/jo0505371 |
| Publication Date | 15 Jun 2005 |
| Publication Type | Article |
| Researcher | Gonzalo Jiménez-Osés |
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