Detalle de: Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
| Title | Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon |
| Abstract |
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression. |
| Apa Reference | Deonarain, R., Alcamí, A., Alexiou, M., Dallman, M.J., Gewert, D.R. & Porter, A.C.G. (2000). Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon. Journal of Virology, 74(7), 3404-3409. 10.1128/JVI.74.7.3404-3409.2000 |
| Doi | 10.1128/JVI.74.7.3404-3409.2000 |
| Publication Date | Apr 2000 |
| Publication Type | Article |
| Researcher | Antonio Alcamí |
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