Antonio Alcamí
Immunity and Viromics · CBM
Biography
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Research Professor of the CSIC at the Centro de Biología Molecular (CBM) Severo Ochoa, where he leads the Immunity and Viromics laboratory. After his doctoral thesis at the CBM, he moved in 1991 to the University of Oxford (UK) and in 1998 received a Wellcome Trust Senior Fellowship to establish his research group at the University of Cambridge (UK). He joined the CSIC in 2003 and was Honorary Senior Visiting Fellow at the University of Cambridge (UK) until 2012. His research focuses on immune evasion by poxviruses and, since the COVID-19 pandemic, on airborne virus transmission. He works on emerging viruses such as SARS-CoV-2, mpox virus and avian influenza virus. He is also interested in metagenomic studies for the discovery of new viruses in polar environments, describing for the first time the virus community in Antarctic and Arctic lakes. He has carried out 6 campaigns in Antarctica and has been a visiting professor at the University Centre in Svalbard (Norway) in the Arctic. He recently led the CSIC-UNESPA Antarctic Expedition 2025, starting studies on the entry of highly pathogenic avian influenza virus into Antarctica. He was manager (2013-2016) and collaborator (2012, 2017) of the Biomedicine programme of the Ministry of Science and Innovation. He has been an adviser to the World Health Organization Advisory Committee on Variola Virus Research since 1999. He received the Alberto Sols Award for research career in 2018 and is a corresponding academician of the Real Academia Nacional de Farmacia. He has been principal investigator of 50 research projects, including 20 international ones (United Kingdom, USA, New Zealand and European Union). He has published 160 scientific articles in international journals and is inventor of 18 patents. |
Profile
| Institution | CBM |
| Position | Research Professor |
| Home page | https://www.cbm.uam.es/index.php/programas-cientificos/interacciones-con-el-entorno/desarrollo-y-funcion-del-sistema-inmunitario/inmunidad-y-viromica/?lang=en |
| Contact email | aalcami@cbm.csic.es |
| ORCID | 0000-0002-3333-6016 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | |
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Research
Research topics
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Research lines
Publications 163 entries
- Remote Minimally Invasive Techniques for Sample Collection in Antarctic Seals Article · 4 Aug 2026
- Non-cyclic dinucleotide STING agonists abrogate MPXV infection Preprint · 9 Jun 2026
- NRF2 controls a diverse network of antiviral effectors with p62 acting as a central restriction factor effective across virus families Article · Jun 2026
- Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 Article · Mar 2026
- Enhanced virulence of mpox virus clade Ib over clade IIb in the CAST/EiJ mouse model Article · 11 Feb 2026
View all (158 more)
- In memoriam Robert Drillien (1947-2025) Article · Feb 2026
- The expanding H5N1 avian influenza panzootic causes high mortality of skuas in Antarctica Article · 14 Jan 2026
- Antarctic Soil Auxiliarome: unraveling the pan-auxiliary metabolic genes catalogue in a transect across different ice-free regions of Antarctica Preprint · 13 Oct 2025
- Enhanced mouse virulence of mpox virus clade Ib over clade IIb despite genomic changes caused by human-to-human transmission Preprint · 22 Sep 2025
- Virus Inactivation by Catalytic Air Converter Filters: The Role of Coating Methods Article · 28 Aug 2025
- Viral soluble decoy receptor as a novel treatment for IFN-I triggered diseases Preprint · 15 Aug 2025
- Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device Article · 30 May 2025
- Copper–Silver Nanoparticle/Lipase Nanobiohybrids for Enhanced Activity Against Viral Pathogens Article · 13 May 2025
- Fluorescent Clade IIb Lineage B.1 Mpox Viruses for Antiviral Screening Article · 13 Feb 2025
- Antigen receptor ITAMs provide tonic signaling by acting as guanine nucleotide exchange factors to directly activate R-RAS2 Article · 28 Jan 2025
- Viral Strategies to Modulate Cytokine and Chemokine Activities Book / chapter · 2025
- Overview of Viral Immunity Book / chapter · 2025
- Experimental assessment of counterfog bioaerosol fast sampler for virus detection and decontamination Article · 6 Sep 2024
- Poxvirus Immune Evasion Article · 28 Jun 2024
- Inhibition of SARS-CoV-2 3CLpro by chemically modified tyrosinase from Agaricus bisporus Article · 2024
- Nanostructured biohybrid material with wide-ranging antiviral action Article · 22 Jun 2023
- MPXV and SARS-CoV-2 in the air of nightclubs in Spain Article · Jun 2023
- Clear polyurethane coatings with excellent virucidal properties: Preparation, characterization and rapid inactivation of human coronaviruses 229E and SARS-CoV-2 Article · Jun 2023
- Contribution of soil bacteria to the atmosphere across biomes Article · May 2023
- Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2 Article · 28 Apr 2023
- Pathogenesis of the circulating mpox virus and its adaptation to humans Article · 20 Mar 2023
- Spanish wastewater reveals the current spread of Monkeypox virus Article · Mar 2023
- Monitoring monkeypox virus in saliva and air samples in Spain: a cross-sectional study Article · Jan 2023
- Fast Air-to-Liquid Sampler Detects Surges in SARS-CoV-2 Aerosol Levels in Hospital Rooms Article · 29 Dec 2022
- Detection of Chemokine Binding Proteins Association to Cell Surface Glycosaminoglycans by Flow Cell Cytometry and Indirect Immunofluorescence Book / chapter · 15 Nov 2022
- Copper Nanostructured biohybrid material as broad-spectrum antiviral agent and its application as coating surface material Preprint · 8 Nov 2022
- High-throughput engineering of cytoplasmic- and nuclear-replicating large dsDNA viruses by CRISPR/Cas9 Article · 27 Oct 2022
- Assessment of Surface Disinfection Effectiveness of Decontamination System COUNTERFOG® SDR-F05A+ Against Bacteriophage ɸ29 Article · 19 Jul 2022
- Monkeypox in humans: a new outbreak Article · 6 Jul 2022
- Herpes simplex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity Article · 26 Aug 2021
- TNF Decoy Receptors Encoded by Poxviruses Article · 22 Aug 2021
- Comparative Pathogenesis, Genomics and Phylogeography of Mousepox Article · 15 Jun 2021
- Fast surface disinfection with COUNTERFOG® SDR-F05A+ Article · Apr 2021
- Combination of long- and short-read sequencing fully resolves complex repeats of herpes simplex virus 2 strain MS complete genome Article · 24 Mar 2021
- Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2 Article · 12 Dec 2020
- Poxvirus-encoded TNF receptor homolog dampens inflammation and protects from uncontrolled lung pathology during respiratory infection Article · 12 Oct 2020
- SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate Article · 2 Oct 2020
- Virus-encoded cytokine and chemokine decoy receptors Article · Oct 2020
- Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner Article · 29 Sep 2020
- Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection Article · 18 Sep 2020
- Was smallpox a widespread mild disease? Article · 24 Jul 2020
- Activation of OX40 and CD27 Costimulatory Signalling in Sheep through Recombinant Ovine Ligands Article · 22 Jun 2020
- T cells with dysfunctional mitochondria induce multimorbidity and premature senescence Article · 19 Jun 2020
- Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation Article · 31 Mar 2020
- Deriving Immune Modulating Drugs from Viruses—A New Class of Biologics Article · 31 Mar 2020
- Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor Article · 20 Dec 2019
- Temporal patterns of variability for prokaryotic and eukaryotic diversity in the urban air of Madrid (Spain) Article · Nov 2019
- Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor Article · 4 Apr 2019
- Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor Article · Mar 2019
- A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding Article · 21 Dec 2018
- Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines Article · 7 Nov 2018
- Mechanism of action of the viral chemokine-binding protein E163 from ectromelia virus Article · Nov 2018
- A New Putative Caulimoviridae Genus Discovered through Air Metagenomics Article · 11 Oct 2018
- Complete Genome Sequence of Herpes Simplex Virus 2 Strain 333 Article · 6 Sep 2018
- New insights into the immunomodulatory properties of poxvirus cytokine decoy receptors at the cell surface Article · 11 Jun 2018
- Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation Article · 3 May 2018
- Viruses in Polar Lake and Soil Ecosystems Book / chapter · 2018
- Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A Article · 26 Oct 2017
- Aquatic viral metagenomics: Lights and shadows Article · Jul 2017
- Validation of the Hirst-Type Spore Trap for Simultaneous Monitoring of Prokaryotic and Eukaryotic Biodiversities in Urban Air Samples by Next-Generation Sequencing Article · Jul 2017
- Infection with diverse immune-modulating poxviruses elicits different compositional shifts in the mouse gut microbiome Article · 10 Mar 2017
- Genome Sequence of Herpes Simplex Virus 1 Strain SC16 Article · 26 Jan 2017
- Herpes simplex virus particles interact with chemokines and enhance cell migration Article · 10 Nov 2016
- Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream Article · Oct 2016
- Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1 Article · 30 Aug 2016
- Metagenomic analysis of lacustrine viral diversity along a latitudinal transect of the Antarctic Peninsula Article · 7 Apr 2016
- Composition and Interactions among Bacterial, Microeukaryotic, and T4-like Viral Assemblages in Lakes from Both Polar Zones Article · 18 Mar 2016
- Ecosystem function decays by fungal outbreaks in Antarctic microbial mats Article · 14 Mar 2016
- Chemokines and Viral Infections Book / chapter · 2016
- Immune modulation by virus-encoded secreted chemokine binding proteins Article · Nov 2015
- Establishment of a Zebrafish Infection Model for the Study of Wild-Type and Recombinant European Sheatfish Virus Article · 15 Oct 2015
- Poxvirus-encoded TNF decoy receptors inhibit the biological activity of transmembrane TNF Article · 1 Oct 2015
- Biodiversity and distribution of polar freshwater DNA viruses Article · 5 Jun 2015
- Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors Article · Jun 2015
- Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization Article · 27 Jan 2015
- Secreted Herpes Simplex Virus-2 Glycoprotein G Modifies NGF-TrkA Signaling to Attract Free Nerve Endings to the Site of Infection Article · 22 Jan 2015
- Gut dysbiosis affects early inflammatory brain response to Theiler's murine encephalomyelitis virus infection Article · Oct 2014
- The genome sequence of ectromelia virus Naval and Cornell isolates from outbreaks in North America Article · Aug 2014
- Genome-Wide Analysis of Wild-Type Epstein–Barr Virus Genomes Derived from Healthy Individuals of the 1000 Genomes Project Article · 28 Mar 2014
- Genome Sequence of WAU86/88-1, a New Variant of Vaccinia Virus Lister Strain from Poland Article · 27 Feb 2014
- β‐arrestin‐1 mediates the TCR‐triggered re‐routing of distal receptors to the immunological synapse by a PKC‐mediated mechanism Article · 6 Feb 2014
- Evaluation of viral genome assembly and diversity estimation in deep metagenomes Article · 2014
- An orphan viral TNF receptor superfamily member identified in lymphocystis disease virus Article · 7 Jun 2013
- Crosstalk between the Type 1 Interferon and Nuclear Factor Kappa B Pathways Confers Resistance to a Lethal Virus Infection Article · Jun 2013
- Complete Genome Sequence of the European Sheatfish Virus Article · Jun 2012
- The Genome Sequence of the Emerging Common Midwife Toad Virus Identifies an Evolutionary Intermediate within Ranaviruses Article · Apr 2012
- Enhancement of Chemokine Function as an Immunomodulatory Strategy Employed by Human Herpesviruses Article · 2 Feb 2012
- Antibody Inhibition of a Viral Type 1 Interferon Decoy Receptor Cures a Viral Disease by Restoring Interferon Signaling in the Liver Article · 5 Jan 2012
- Ectromelia NF-κβ inhibitor 002 is essential for virus pathogenesis (154.4) Article · 1 Apr 2011
- Glycosaminoglycans mediate retention of the poxvirus type I interferon binding protein at the cell surface to locally block interferon antiviral responses Article · 3 Mar 2011
- Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD Article · Nov 2010
- Poxviral TNFRs: Properties and Role in Viral Pathogenesis Book / chapter · 22 Oct 2010
- The interaction of viruses with host immune defenses Article · Aug 2010
- Modulation of chemokine activity by viruses Article · Aug 2010
- Interferon-α/β Genes Are Up-Regulated in Murine Brain Astrocytes After Infection With Theiler’s Murine Encephalomyelitis Virus Article · Apr 2010
- Evaluation of immunological responses to a glycoprotein G deficient candidate vaccine strain of infectious laryngotracheitis virus Article · Feb 2010
- The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon Article · 17 Dec 2009
- High Diversity of the Viral Community from an Antarctic Lake Article · 6 Nov 2009
- Immune modulation by virus-encoded cytokine binding proteins Article · Oct 2009
- Glycoprotein G from pseudorabies virus binds to chemokines with high affinity and inhibits their function Article · 23 Sep 2009
- Expression of the Chemokine Binding Protein M3 Promotes Marked Changes in the Accumulation of Specific Leukocytes Subsets Within the Intestine Article · Sep 2009
- Identification of TRIM23 as a Cofactor Involved in the Regulation of NF-κB by Human Cytomegalovirus Article · 15 Apr 2009
- A Method for the Generation of Ectromelia Virus (ECTV) Recombinants: In Vivo Analysis of ECTV vCD30 Deletion Mutants Article · 13 Apr 2009
- Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components Article · 15 Feb 2009
- A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis Article · Feb 2009
- Chapter 8 Identification and Characterization of Virus‐Encoded Chemokine Binding Proteins Book / chapter · 2009
- Chemokine Binding Proteins Encoded by Pathogens Book / chapter · 2009
- A pro‐inflammatory signature mediates FGF2‐induced angiogenesis Article · 9 Jul 2008
- NF-κB-Mediated Activation of the Chemokine CCL22 by the Product of the Human Cytomegalovirus Gene UL144 Escapes Regulation by Viral IE86 Article · May 2008
- An Ectromelia Virus Protein That Interacts with Chemokines through Their Glycosaminoglycan Binding Domain Article · 15 Jan 2008
- New insights into the subversion of the chemokine system by poxviruses Article · 28 Mar 2007
- Heterologous Priming-Boosting with DNA and Modified Vaccinia Virus Ankara Expressing Tryparedoxin Peroxidase Promotes Long-Term Memory against Leishmania major in Susceptible BALB/c Mice Article · Feb 2007
- Pathogen-derived immunomodulatory molecules: future immunotherapeutics? Article · Oct 2006
- The UL144 gene product of human cytomegalovirus activates NFκB via a TRAF6‐dependent mechanism Article · 24 Aug 2006
- A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus Article · 11 Apr 2006
- Both soluble and membrane-anchored forms of Felid herpesvirus 1 glycoprotein G function as a broad-spectrum chemokine-binding protein Article · 1 Dec 2005
- Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity Article · 21 Nov 2005
- Virally Encoded Chemokine Binding Proteins Article · 1 Sep 2005
- IL-10 from Regulatory T Cells Determines Vaccine Efficacy in Murine Leishmania major Infection Article · Aug 2005
- The chemokine receptor D6 limits the inflammatory response in vivo Article · 6 Mar 2005
- Inhibition of Intimal Hyperplasia in Transgenic Mice Conditionally Expressing the Chemokine-Binding Protein M3 Article · Jun 2004
- The gammaherpesvirus chemokine binding protein can inhibit the interaction of chemokines with glycosaminoglycans Article · 20 Jan 2004
- Genetic Variability of Immunomodulatory Genes in Ectromelia Virus Isolates Detected by Denaturing High-Performance Liquid Chromatography Article · 15 Sep 2003
- The Gammaherpesvirus Chemokine Binding Protein Binds to the N Terminus of CXCL8 Article · Aug 2003
- Structural basis of the herpesvirus M3–chemokine interaction Article · May 2003
- Glycoprotein G isoforms from some alphaherpesviruses function as broad‐spectrum chemokine binding proteins Article · 17 Feb 2003
- Viral mimicry of cytokines, chemokines and their receptors Article · 1 Jan 2003
- Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68 Article · Jan 2003
- Viruses in control of the immune system Article · 1 Oct 2002
- Inhibition of Type 1 Cytokine–mediated Inflammation by a Soluble CD30 Homologue Encoded by Ectromelia (Mousepox) Virus Article · 16 Sep 2002
- Inhibition of Interferons by Ectromelia Virus Article · Feb 2002
- CrmE, a Novel Soluble Tumor Necrosis Factor Receptor Encoded by Poxviruses Article · Jan 2001
- The Vaccinia Virus Soluble Alpha/Beta Interferon (IFN) Receptor Binds to the Cell Surface and Protects Cells from the Antiviral Effects of IFN Article · Dec 2000
- Soluble chemokine binding proteins are also encoded by herpesviruses Article · Oct 2000
- Expression of Secreted Cytokine and Chemokine Inhibitors by Ectromelia Virus Article · 15 Sep 2000
- Viral mechanisms of immune evasion Article · Sep 2000
- Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon Article · Apr 2000
- RANTES Binding and Down-Regulation by a Novel Human Herpesvirus-6 β Chemokine Receptor Article · 1 Mar 2000
- A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus Article · 7 Feb 2000
- Poxviruses: Interfering with Interferon Article · Apr 1998
- Poxviruses: Capturing Cytokines and Chemokines Article · Apr 1998
- Vaccinia virus immune evasion Article · Oct 1997
- Analysis of an Interaction between the Soluble Vaccinia Virus-Coded Type I Interferon (IFN)-Receptor and Human IFN-α1 and IFN-α2 Article · May 1997
- Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever. Article · 1 Mar 1997
- A mechanism for the inhibition of fever by a virus. Article · Oct 1996
- Soluble interferon-γ receptors encoded by poxviruses Article · Sep 1996
- Receptors for gamma-interferon encoded by poxviruses: implications for the unknown origin of vaccinia virus Article · Aug 1996
- Cytokine receptors encoded by poxviruses: a lesson in cytokine biology Article · Oct 1995
- Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity Article · May 1995
- Comment on the paper by Shchelkunov et al. (1993) FEBS Letters 319, 80‐83. Two genes encoding poxvirus cytokine receptors are disrupted or deleted in variola virus Article · 29 Nov 1993
- Mapping and sequence of the gene encoding the African swine fever virion protein of Mr 11500 Article · 1 Nov 1993
- Inhibition of African swine fever virus binding and infectivity by purified recombinant virus attachment protein p12 Article · Sep 1993
- Virus-host interactions in African swine fever: the attachment to cellular receptors Book / chapter · 1993
- A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection Article · Oct 1992
- Fc receptors do not mediate african swine fever virus replication in macrophages Article · Apr 1991
- Interaction of African swine fever virus with macrophages Article · Oct 1990
- The entry of African swine fever virus into Vero cells Article · Jul 1989
- Saturable binding sites mediate the entry of African swine fever virus into VERO cells Article · Feb 1989
