Detalle de: Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma
| Title | Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma |
| Abstract |
SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple “-omics” methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our LUAD cohort (41.4%), and over 70% of the mutations were predicted to have functional impact. Furthermore, SWI/SNF expression in LUAD suffered an overall repression that could not be explained exclusively by genetic alterations. Finally, SWI/SNF mutations were associated with poorer overall survival in TCGA-LUAD. We propose SWI/SNF-mutant LUAD as a separate clinical subgroup with practical implications. |
| Apa Reference | Peinado, P., Andrades, A., Cuadros, M., Rodriguez, M.I., Coira, I.F., Garcia, D.J., Benitez-Cantos, M.S., Cano, C., Zarzuela, E., Muñoz, J., Loidi, C., Saiz, M. & Medina, P.P. (2022). Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma. Clinical Epigenetics, 14(1). 10.1186/S13148-022-01261-3 |
| Doi | 10.1186/S13148-022-01261-3 |
| Publication Date | 17 Mar 2022 |
| Publication Type | Article |
| Researcher | Daniel Jesús García García |
| Ontology | Omics, Mutation Analysis and design |
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