Research Group

Detalle de: Biocomputing Unit at CNB

Title	Biocomputing Unit at CNB
Description	Developing the new generation of algorithms and software to extract biological knowledge from cryo Electron Microscopy images. Started in 1989 and headed by Dr. Jose Maria Carazo and Carlos Oscar Sanchez Sorzano, the Biocomputing Unit (BCU) of the National Center for Biotechnology / Instruct Image Processing Center (I2PC) works in the area of cryo electron microscopy. We develop new ways to extract information from very noisy electron microscopy images obtained under cryogenic conditions, and we integrate these new tools into advanced image processing software packages such as XMIPP and Scipion, together with integrative biological environments such as 3DBIONOTES. The research team works in new computational and experimental methodologies to solve key problems in biology and their first application to a number of key specimens. Our approach is focused on: Structural Biology by cryo Electron Microscopy; Biomedical Information Integration; Scientific Computing.
Home Page	https://biocomputingunit.es
Contact Email	bioinfo@cnb.csic.es
Collaborating Companies
Spin Off
Patents
Hpc Resources
Institution	CNB
Ontology	Computational Methods, Machine Learning in Biology, Bioinformatics Software and Tools, Structural bioinformatics, Experimental structure determination, Systems Biology, Statistical Methods for Biology, Image analysis, Cryo-electron microscopy
Tools	Scipion, Xmipp, 3DBionotes, COVID-19 Structural Hub, (cryo-EM) Validation Report Service, Scipion-Chem
Service Units	Instruct Image Processing Center (I2PC) at CNB
Research Lines
Funded Projects	A synergistic approach toward understanding receptor signaling in the cell at very high resolution, Fully three-dimensional image reconstruction from transmission electron-microscopy projections, Bioimage: A european database of biological volume images, Desarrollo y aplicación al sistema de las helicasas hexaméricas de nuevas estrategias de reconstrucción tridimensional a resolución macromolecular, Análisis estructural del antígeno T de SV40: Su caracterización estructural y el desarrollo de nuevas técnicas de procesamiento de imágenes multidimensionales, Reconstrucción tridimensional en microscopía electrónica: Organización de volúmenes en la base de datos BioImage, desarrollo de nuevas metodologías de procesamiento de imagenm y aplicación al estudio estructural de diversas helicasas hexaméricas, Integration of information about macromolecular structure, Image processing in biological 3D electron microscopy, Análisis estructural a resolución media de macromoléculas biológicas: una aproximación conjunta desde la biología y la bioinformática estructural, Hacia la comprensión de la riqueza estructural de las nanomáquinas moleculares, Técnicas de procesamiento de señales multidimensionales aplicadas a biología estructural mediante microscopía electrónica, New electron microscopy approaches for studying protein complexes and cellular supramolecular architecture, Técnicas de procesamiento de señales multidimensionales aplicadas a biología estructural mediante microscopía electrónica, Image Processing in Biological 3D Electron Microscopy, Hacia la proteómica funcional: una aproximacion conjunta desde la proteómica, la bioinformática y la biología estructural, Análisis de grandes cantidades de imágenes de microscopia electrónica tridimensional: desarrollo de métodos y aplicación al análisis del replisoma, Tomografía de rayos X: una herramienta de integración entre biología molecular y celular, Associated Center for Image Processing in Microscopy for Structural Biology, Four-dimensional cryo-transmission electron microscopy of large macromolecular assemblies, Parallel-Scalable Single-Particle Analysis in 3D Electron Microscopy, Puesta en marcha del Centro Asociado INSTRUCT en procesamiento de imágenes en Microscopía, Hacia una microscopía electrónica tridimensional de alto rendimiento, Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray facilities, Comienzo de la fase operativa del Instruct Image Processing Center, Four-dimensional transmission electron microscopy of macromolecular assemblies, Procesamiento tridimensional de imagen robusto y automatizado en Biología Estructural, Coordinated Research Infrastructures Building Enduring Life-science services, Infrastructure for NMR, EM and X-ray crystallography for translational research, World-wide E-infrastructure for structural biology, Análisis en alto rendimiento de flexibilidad estructural tanto por criomicroscopía electrónica como por criomicroscopía de rayos X blandos, Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research, Infrastructure for transnational access and discovery in structural biology, Procesamiento de imagen avanzado orientado al análisis de partículas individuales en microscopía electrónica en condiciones criogénicas, Towards enhancing throughput in streaming cryo Electron Microscopy lmage Processing, Beyond COVID, From fragments to high affinity binders interfacing integrated structural biology, medicinal chemistry and artificial intelligence, Integrated Services for Infectious Disease Outbreak Research, Mejorando la capacidad de análisis estructural de la criomicroscopía electrónica, Improving the quality of global and ligand-centric features in cryo-EM maps, A Hybrid AI-model for Resolving Molecular Structures integrating sequence and Cryo-Electron Microscopy data, Computational search of ligands for macromolecular targets
Selected Publications	—
Researchers	Carlos Oscar Sorzano, Jose María Salvador Carazo Garcia, Roberto Marabini Ruiz

Suggest changes

← Return to Home