Detalle de: Epigenetic silencing of LINE-1 retrotransposons
| Title | Epigenetic silencing of LINE-1 retrotransposons |
| Description |
How the youngest human LINE-1 elements (L1HS) are identified and silenced by de novo DNA methylation during early embryonic reprogramming, why specific copies escape silencing and remain active in adult tissues, and the role of the transcription factor YY1 and its binding site in this pathway; locus-specific CRISPR-Cas9 editing of L1HS promoters in human embryonic stem cells. |
| Research Groups | Molecular Genetics Of Mobile And Foreign DNA |
| Researchers | Sara Esther Ramos Lorente |