David Ángel Abia Holgado
Biography
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David Abia is responsible for the "Analysis and modelling of systems and biomolecules" service area (formerly the CBM Bioinformatics Service) of the Biocomputing and Omics Integration Facility (SBIO) at the Centro de Biología Molecular Severo Ochoa (CSIC-UAM). The area supports CBM research groups and external users with sequence analysis and phylogenies, protein structure prediction (AlphaFold) and modelling of complexes, molecular dynamics simulations, evaluation of interactions and mutations, and machine learning, providing access to local clusters and external HPC resources (CSIC, RES, Google Cloud), from raw data to publication-ready results. |
Profile
| Institution | CBM |
| Position | Head of the Analysis and Modelling of Systems and Biomolecules area, Biocomputing and Omics Integration Facility (SBIO), CBM |
| Home page | https://digital.csic.es/cris/rp/rp12441?open=journal&author_page=1 |
| Contact email | dabia@cbm.csic.es |
| ORCID | 0000-0003-0401-7590 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | |
| BCB Services | Biocomputing and Omics Integration Facility (SBIO) at CBM |
Research
Research topics
Machine Learning in BiologyHigh-performance ComputingSequence analysisPhylogenetic AnalysisMutation Analysis and designBiomolecular simulationStructure prediction
Research lines
None
Publications 47 entries
- Expression of conjugation genes is controlled by a novel zipper-type transcriptional attenuation mechanism Article · 17 Jul 2026
- A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli Article · 5 Sep 2025
- Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions Article · 25 Jul 2025
- A Drosophila ecdysone-deficient model to assess the endocrine disruptor activity of Bisphenol A Article · Jul 2025
- KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging Article · 30 Apr 2025
View all (42 more)
- Time-resolved mitochondrial screen identifies regulatory components of oxidative metabolism Article · 29 Apr 2025
- Extraordinary long-stem confers resistance of intrinsic terminators to processive antitermination Article · 1 May 2023
- Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen Article · 20 Apr 2023
- The B. subtilis Rok protein is an atypical H-NS-like protein irresponsive to physico-chemical cues Article · 21 Nov 2022
- A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength Article · 26 May 2022
- Vaccine Type-, Age- and Past Infection-Dependence of the Humoral Response to SARS-CoV-2 Spike S Protein Article · 28 Feb 2022
- Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia Article · 4 Feb 2022
- Establishment Genes Present on pLS20 Family of Conjugative Plasmids Are Regulated in Two Different Ways Article · 29 Nov 2021
- pLS20 is the archetype of a new family of conjugative plasmids harboured by Bacillus species Article · 4 Oct 2021
- A novel bipartite antitermination system widespread in conjugative elements of Gram-positive bacteria Article · 17 May 2021
- A Conserved Class II Type Thioester Domain-Containing Adhesin Is Required for Efficient Conjugation in Bacillus subtilis Article · 27 Apr 2021
- Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein Article · 17 Feb 2021
- RRAS2 shapes the TCR repertoire by setting the threshold for negative selection Article · 19 Jul 2019
- Surface Exclusion Revisited: Function Related to Differential Expression of the Surface Exclusion System of Bacillus subtilis Plasmid pLS20 Article · 10 Jul 2019
- Novel regulatory mechanism of establishment genes of conjugative plasmids Article · 31 Oct 2018
- Modification of a Putative Third Sodium Site in the Glycine Transporter GlyT2 Influences the Chloride Dependence of Substrate Transport Article · 24 Sep 2018
- In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization Article · 15 Jun 2018
- The Bacillus subtilis Conjugative Plasmid pLS20 Encodes Two Ribbon-Helix-Helix Type Auxiliary Relaxosome Proteins That Are Essential for Conjugation Article · 3 Nov 2017
- Environment-dependent regulation of spliceosome activity by the LSM2-8 complex in Arabidopsis Article · 8 May 2017
- Nonketotic hyperglycinemia: Functional assessment of missense variants in GLDC to understand phenotypes of the disease Article · 20 Mar 2017
- Discovery of a new family of relaxases in Firmicutes bacteria Article · 16 Feb 2017
- First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases Article · 21 Dec 2016
- An Efficient Microarray-Based Genotyping Platform for the Identification of Drug-Resistance Mutations in Majority and Minority Subpopulations of HIV-1 Quasispecies Article · 13 Dec 2016
- Crammed signaling motifs in the T-cell receptor Article · Sep 2014
- Major Groove Binding Track Residues of the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Enhance cDNA Synthesis at High Temperatures Article · 12 Dec 2013
- Functional characterization of novel genotypes and cellular oxidative stress studies in propionic acidemia Article · 3 Oct 2012
- A Viral, Transporter Associated with Antigen Processing (TAP)-independent, High Affinity Ligand with Alternative Interactions Endogenously Presented by the Nonclassical Human Leukocyte Antigen E Class I Molecule Article · Oct 2012
- MM-ISMSA: An Ultrafast and Accurate Scoring Function for Protein–Protein Docking Article · 14 Aug 2012
- Highly sensitive molecular diagnosis of prostate cancer using surplus material washed off from biopsy needles Article · 18 Oct 2011
- Expression analysis revealing destabilizing mutations in phosphomannomutase 2 deficiency (PMM2‐CDG) Article · 4 May 2011
- The amino terminal end determines the stability and assembling capacity of eukaryotic ribosomal stalk proteins P1 and P2 Article · 18 Jan 2011
- Structural characterization of the TCR complex by electron microscopy Article · Nov 2010
- Discovery of genomic alterations through coregulation analysis of closely linked genes: a frequent gain in 17q25.3 in prostate cancer Article · Oct 2010
- Functional and structural analysis of five mutations identified in methylmalonic aciduria cbIB type Article · 15 Jun 2010
- Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon Article · 5 Feb 2010
- An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis Article · 9 Dec 2009
- Modifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exon Article · Sep 2009
- The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein Article · 3 Apr 2009
- Co-regulation analysis of closely linked genes identifies a highly recurrent gain on chromosome 17q25.3 in prostate cancer Article · 30 Oct 2008
- Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment Article · 18 May 2006
- Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data Article · 17 Aug 2005
- Two New Alleles of the abscisic aldehyde oxidase 3 Gene Reveal Its Role in Abscisic Acid Biosynthesis in Seeds Article · 1 May 2004