Researcher

Paulino Gomez-Puertas

Biography

Paulino Gómez-Puertas (Santa María del Páramo, León, Spain, 1965) is a Research Scientist (Científico Titular) of the Spanish National Research Council (CSIC) at the Centro de Biología Molecular Severo Ochoa (CSIC-UAM), and Associated Researcher of the Institute for Health Research of La Paz University Hospital (IdiPAZ). His group studies macromolecular complexes of biomedical interest by molecular dynamics simulation and develops efficient structure-based drug design methods based on computational dynamic simulation of macromolecular structures.

Academic degrees. B.Sc. in Biological Sciences (1986), M.Sc. in Biochemistry and Molecular Biology (1988) and Ph.D. in Biochemistry and Molecular Biology (1992), all at the Universidad Autónoma de Madrid.

Career. Undergraduate (1983) and PhD student (1989) at the Department of Biochemistry and Molecular Biology, Universidad Autónoma de Madrid. Postdoctoral researcher at the Centro de Biología Molecular Severo Ochoa (CSIC, 1992), the Centro de Investigación en Sanidad Animal (CISA-INIA, 1993) and the Centro Nacional de Biología Fundamental (ISCIII, 1997); visiting scientist at the N.E.R.C. Institute of Virology and Environmental Microbiology, Oxford (1998); postdoctoral researcher in the Protein Design Group of the Centro Nacional de Biotecnología (CSIC, 2000). Research Scientist of CSIC since 2002, at the Centro de Biología Molecular Severo Ochoa since 2004, and Honorary Professor at the Universidad Autónoma de Madrid (2003-2008). In 2006 he coordinated the Bioinformatics modules of the UAM Master's programmes in Molecular Biology and in Biomedicine. Associated Researcher at IdiPAZ since 2012, and member of the CSIC networks "Conexión Cáncer" (since 2021), "Computational Biology and Bioinformatics" (since 2023) and the Rare Diseases Network RER-CSIC (since 2024).

Awards and scientific societies. Doctorate Prize of the Universidad Autónoma de Madrid (1992); "Juan Abelló" Biochemistry Award of the Spanish Royal Academy of Doctors (1994). Member of the Spanish Society for Biochemistry and Molecular Biology (SEBBM, since 1992) and of the Spanish Association of Human Genetics (AEGH, since 2013).

Journals. Associate editor of the World Journal of Microbiology and Biotechnology (since 2026); academic editor of the International Journal of Biological Macromolecules (2024-2025), the International Journal of Molecular Sciences, sections Molecular Biology and Molecular Biophysics (2018-2025), and Biophysica (2022-2025). Referee for international journals in bioinformatics and molecular biology.

Project evaluation. Evaluator of project proposals for the Spanish National Evaluation and Foresight Agency (ANEP), the Agency for Administration of University and Research Grants of Catalonia, the Research, Development and Innovation office of Galicia, the Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, Argentina), the Comisión Sectorial de Investigación Científica (CSIC-Uruguay), the National Evaluation and Foresight Commission (FONCECYT-CONICYT, Chile) and the University of Macau.

Science policy and committees. Member of the Informatics Commission (2006) and of the Bioinformatics Commission (2023) of the CBM; participant in the CSIC "Science4Policy" initiative with the report "Bacterial resistance to antibiotics" (2023).

Technology transfer. In 2007 he founded Biomol-Informatics SL, a spin-off company of the Madrid Science Park, which participated in the EU FP7 consortia DIVINOCELL (2009), DORIAN (2012) and Epi-TRAITS (Marie Curie ITN, 2012), in the IMI-ENABLE consortium of the Innovative Medicines Initiative New Drugs for Bad Bugs programme (2014), and coordinated the DIGEN-1K consortium (Madrid Science Park, IdiPAZ, CSIC; Plan Nacional I+D+I 2011). R&D contract in bioinformatics between Biomol-Informatics SL and the Fundación Severo Ochoa (2008-2017). Co-inventor of the patent "Soluble miniACE2 proteins that interact with SARS-CoV-2 and uses thereof" (PCT/IB2023/054335, WO/2023/209619), in collaboration with the Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud (IDCBIS) of Bogotá, Colombia.

Publication metrics (May 2026). Web of Science h-index 46; Scopus h-index 44; Research.com D-index 52; ResearchGate h-index 50; Google Scholar i10-index 114. Ranked #15475 worldwide and #371 in Spain among the best Biology and Biochemistry scientists by Research.com (2026).

Profile

Institution	CBM
Position	Research Scientist CSIC
Home page	http://bioweb.cbm.uam.es/
Contact email	pagomez@cbm.csic.es
ORCID	0000-0003-3131-729X

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BCB Committee	Support BCB Excellence
BCB Tools	MEPSA: Minimum Energy Pathway Analysis for energy landscapes., MEPSAnd: minimum energy path surface analysis over n-dimensional surfaces.
BCB Services

Research

Research topics

Computational MethodsStructural bioinformaticsComputational models and simulationsBiomolecular simulationStructure-function relationshipDrug Discovery and designStructure predictionMolecular Interactions/DockingProtein/Nucleic Acid design

Research lines

Projects, networks, transfer & teaching

Research networks

National

CSIC "Conexión Cáncer" network (since 2021)
CSIC "Computational Biology and Bioinformatics" network (since 2023)
CSIC Rare Diseases Network, RER-CSIC (since 2024)

International

CONNECT - JPIAMR Virtual Research Institute Network (2018-2020)
EPIC Alliance - Alliance for the Exploration of Pipelines for Inhibitors of Carbapenemases, JPIAMR Network Plus (2020-2023)

Industry & knowledge transfer

Collaborating companies

Biomol-Informatics SL (R&D contract in bioinformatics with the Fundación Severo Ochoa, 2008-2017)

Spin-offs

Biomol-Informatics SL (founder, 2007) - spin-off company of the Madrid Science Park (Parque Científico de Madrid)

Patents

Soluble miniACE2 proteins that interact with SARS-CoV-2 and uses thereof (2022). Patent no. PCT/IB2023/054335 [WO/2023/209619]. In collaboration with the Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud (IDCBIS), Bogotá, Colombia.

Teaching

Master programs

Master in Molecular Biology - Universidad Autónoma de Madrid (coordinator of the Bioinformatics module, 2006)
Master in Biomedicine - Universidad Autónoma de Madrid (coordinator of the Bioinformatics module, 2006)

Funded projects 20

View all (16 more)

Publications 142 entries

View all (137 more)

Postzygotic mosaicism in SMC1A and the first reported case of a female with Cornelia de Lange syndrome Article · 1 Jul 2025
Biallelic loss-of-function variants in ZNF142 are associated with a robust DNA methylation signature affecting a limited number of genomic loci Article · 23 May 2025
An engineered miniACE2 protein secreted by mesenchymal stromal cells effectively neutralizes multiple SARS-CoV- 2 variants in vitro Article · 23 Apr 2025
In Silico Design of miniACE2 Decoys with In Vitro Enhanced Neutralization Activity against SARS-CoV-2, Encompassing Omicron Subvariants Article · 8 Oct 2024
Structural Basis for Alternative Self-Assembly Pathways Leading to Different Human Immunodeficiency Virus Capsid-Like Nanoparticles Article · 27 Sep 2024
STAG2-RAD21 complex: A unidirectional DNA ratchet mechanism in loop extrusion Article · Sep 2024
The phenotypic and genotypic spectrum of individuals with mono‐ or biallelic ANK3 variants Article · 11 Jul 2024
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy Article · 30 Mar 2024
STAG2: Computational Analysis of Missense Variants Involved in Disease Article · 20 Jan 2024
Structural and functional insights into GSDMB isoforms complex roles in pathogenesis Article · 18 Oct 2023
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells Article · 11 Mar 2023
Computational Modeling and Design of New Inhibitors of Carbapenemases: A Discussion from the EPIC Alliance Network Article · 28 Aug 2022
Molecular Basis of the Schuurs–Hoeijmakers Syndrome: What We Know about the Gene and the PACS-1 Protein and Novel Therapeutic Approaches Article · 25 Aug 2022
A Novel Intragenic Duplication in the HDAC8 Gene Underlying a Case of Cornelia de Lange Syndrome Article · 8 Aug 2022
Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder Article · 8 Jun 2022
Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase Article · 27 Apr 2022
Neurodevelopmental Disorders Associated with PSD-95 and Its Interaction Partners Article · 15 Apr 2022
CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative Article · 4 Feb 2022
The clinical and molecular spectrum of QRICH1 associated neurodevelopmental disorder Article · 11 Dec 2021
Things are not always what they seem: From Cornelia de Lange to KBG phenotype in a girl with genetic variants in NIPBL and ANKRD11 Article · 7 Oct 2021
Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia Article · Oct 2021
Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood Article · 29 Jul 2021
DLG4-related synaptopathy: a new rare brain disorder Article · May 2021
Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome Article · 8 Feb 2021
Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome Article · 23 Jun 2020
VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy Article · May 2020
Molecular Characterization of Tc964, A Novel Antigenic Protein from Trypanosoma cruzi Article · 31 Mar 2020
Delineation of phenotypes and genotypes related to cohesin structural protein RAD21 Article · 19 Mar 2020
Evaluating Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes Article · 4 Feb 2020
More Than One HMG-CoA Lyase: The Classical Mitochondrial Enzyme Plus the Peroxisomal and the Cytosolic Ones Article · 4 Dec 2019
MEPSAnd: minimum energy path surface analysis over n-dimensional surfaces Software · 16 Aug 2019
A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 – Review of the literature Article · Jun 2019
Identification of temperature-sensitive mutations and characterization of thermolabile RNase II variants Article · 28 Dec 2018
Population structure of OXA-48-producing Klebsiella pneumoniae ST405 isolates during a hospital outbreak characterised by genomic typing. Article · Dec 2018
Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients Article · 28 Mar 2018
Two-step ATP-driven opening of cohesin head Article · 12 Jun 2017
A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases Article · 1 Jun 2017
mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de Lange Syndrome Article · 23 Feb 2017
Quantum Mechanics/Molecular Mechanics Free Energy Maps and Nonadiabatic Simulations for a Photochemical Reaction in DNA: Cyclobutane Thymine Dimer Article · 25 Oct 2016
In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa Article · 6 Oct 2016
Special Cases in Cornelia de Lange Syndrome: The Spanish Experience Article · 10 May 2016
The Cell Division Protein FtsZ from Streptococcus pneumoniae Exhibits a GTPase Activity Delay Article · Oct 2015
Modulating the RNA Processing and Decay by the Exosome: Altering Rrp44/Dis3 Activity and End-Product (vol 8, e76504, 2013) Article · 21 Aug 2015
MEPSA: minimum energy pathway analysis for energy landscapes Software · 31 Jul 2015
ANISERP: a new serpin from the parasite Anisakis simplex Article · 28 Jul 2015
Comparing Molecular Dynamics Force Fields in the Essential Subspace Article · 26 Mar 2015
De Novo Heterozygous Mutations in SMC3 Cause a Range of Cornelia de Lange Syndrome-Overlapping Phenotypes Article · 17 Mar 2015
A Practical Quantum Mechanics Molecular Mechanics Method for the Dynamical Study of Reactions in Biomolecules Book / chapter · 2015
Design of clone-specific probes from genome sequences for rapid PCR-typing of outbreak pathogens Article · Nov 2014
Severe ipsilateral musculoskeletal involvement in a Cornelia de Lange patient with a novel NIPBL mutation Article · Sep 2014
Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients Article · Jun 2014
FIREBALL/AMBER: An Efficient Local-Orbital DFT QM/MM Method for Biomolecular Systems Article · 2 May 2014
Somatic mosaicism in a Cornelia de Lange syndrome patient with NIPBL mutation identified by different next generation sequencing approaches Article · 26 Jan 2014
Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN Article · 2014
Torsion and curvature of FtsZ filaments Article · 2014
New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations Article · Aug 2013
Analysis of aberrant splicing and nonsense-mediated decay of the stop codon mutations c.109G > T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency Article · Apr 2013
Ddi1-like protein from Leishmania major is an active aspartyl proteinase Article · Mar 2013
Simulation of Catalytic Water Activation in Mitochondrial F-1-ATPase Using a Hybrid Quantum Mechanics/Molecular Mechanics Approach: An Alternative Role for beta-Glu 188 Article · 25 Jan 2013
Genome Sequence of OXA-48 Carbapenemase-Producing Klebsiella pneumoniae KpO3210 Article · 15 Dec 2012
Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity Article · 15 Oct 2012
The only exoribonuclease present in Haloferax volcanii has an unique response to temperature changes Article · Oct 2012
Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol Article · Oct 2012
Surface-Enhanced Raman Scattering-Based Detection of the Interactions between the Essential Cell Division FtsZ Protein and Bacterial Membrane Elements Article · 27 Jul 2012
Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ Article · 28 Mar 2012
Molecular dynamics analysis of conformational change of paramyxovirus F protein during the initial steps of membrane fusion Article · Mar 2012
The role of Gln(61) in HRas GTP hydrolysis: a quantum mechanics/molecular mechanics study (vol 102, pg 152, 2012 ) Article · Mar 2012
The Role of GIn(61) in HRas GTP Hydrolysis: A Quantum Mechanics/Molecular Mechanics Study Article · Jan 2012
Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway Article · 28 Sep 2011
Swapping the domains of exoribonucleases RNase II and RNase R: Conferring upon RNase II the ability to degrade ds RNA Article · 4 Apr 2011
Nanomechanics of the Cadherin Ectodomain "CANALIZATION" BYCa2 BINDING RESULTS IN A NEW MECHANICAL ELEMENT Article · Mar 2011
Technical phosphoproteomic and bioinformatic tools useful in cancer research. Article · 2011
The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens Article · 11 Nov 2010
Neutralization of Human Respiratory Syncytial Virus Infectivity by Antibodies and Low-Molecular-Weight Compounds Targeted against the Fusion Glycoprotein Article · 15 Aug 2010
Strong FtsZ is with the force: mechanisms to constrict bacteria Article · Aug 2010
CDKN1C (p57(Kip2)) Analysis in Beckwith-Wiedemann Syndrome (BWS) Patients: Genotype-Phenotype Correlations, Novel Mutations, and Polymorphisms Article · 14 May 2010
Mutations and Variants in the Cohesion Factor Genes NIPBL, SMC1A, and SMC3 in a Cohort of 30 Unrelated Patients With Cornelia de Lange Syndrome Article · 26 Mar 2010
Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin Article · Jul 2009
Determination of Key Residues for Catalysis and RNA Cleavage Specificity ONE MUTATION TURNS RNase II INTO A "SUPER-ENZYME" Article · Jul 2009
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight Article · Mar 2009
Ten Novel HMGCL Mutations in 24 Patients of Different Origin with 3-Hydroxy-3-Methyl-Glutaric Aciduria Article · 28 Jan 2009
The structure of CCT-Hsc70(NBD) suggests a mechanism for Hsp70 delivery of substrates to the chaperonin Article · 27 Jul 2008
New insights into the mechanism of RNA degradation by ribonuclease II - Identification of the residue responsible for setting the RNase II end product Article · May 2008
Residues in human respiratory syncytial virus P protein that are essential for its activity on RNA viral synthesis Article · Mar 2008
Structural properties of the human respiratory syncytial virus P protein: Evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors Article · 25 Feb 2008
An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions - Relevance for Gaucher disease Article · 2 Jan 2008
Molecular genetics of HMG-CoA lyase deficiency Article · Nov 2007
Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A Article · Jun 2007
C-terminal end and aminoacid Lys(48) in HMG-CoA lyase are involved in substrate binding and enzyme activity Article · Jun 2007
Control of the respiratory metabolism of Thermus thermophilus by the nitrate respiration conjugative element NCE Article · 24 Apr 2007
Quasi-atomic model of bacteriophage T7 procapsid shell: Insights into the structure and evolution of a basic fold Article · Apr 2007
Ca2+ activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin - Role in the heart malate-aspartate NADH shuttle Article · Mar 2007
The role of the S1 domain in exoribonucleolytic activity: Substrate specificity and multimerization Article · 22 Jan 2007
Mutational Spectrum of Maple Syrup Urine Disease in Spain Article · Jul 2006
Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase Article · 25 Apr 2006
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation Article · 14 Mar 2006
A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase Article · Feb 2006
Computational approaches to model ligand selectivity in drug design Article · 1 Jan 2006
Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients Article · Dec 2005
Scoring docking models with evolutionary information Article · 24 Jun 2005
Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)(8) TIM Barrel model of HL Article · Apr 2005
Redesign of carnitine acetyltransferase specificity by protein engineering Article · Aug 2004
TRAF family proteins link PKR with NF-kappa B activation Article · 1 May 2004
Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal Article · 1 May 2004
The substrate recognition mechanisms in chaperonins Article · 25 Feb 2004
Sequence and structural alignments of eukaryotic and prokaryotic cytoskeletal proteins Book / chapter · 2004
Bacterial morphogenes Book / chapter · 2004
Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection Article · 1 Dec 2003
A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae Article · Nov 2003
Structural (beta alpha)(8) TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase Article · Aug 2003
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition - Mutation of methionine 593 abolishes malonyl-CoA inhibition Article · Mar 2003
ESF Programme on 'Integrated Approaches for Functional Genomics' Workshop on 'Modelling of Molecular Networks'. Article · Feb 2003
Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA Article · 11 Dec 2002
Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT Article · 1 Dec 2002
Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT Article · 13 Aug 2002
Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I - Mutational analysis of a malonyl-CoA affinity domain Article · Mar 2002
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT) - Mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity Article · Nov 2001
Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins Article · Sep 2001
Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin Article · Aug 2001
Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover Article · Jul 2001
Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs Article · 15 May 2001
Influenza virus matrix protein is the major driving force in virus budding Article · 15 Dec 2000
Rescue of synthetic RNAs into Thogoto and influenza A virus particles using core proteins purified from Thogoto virus Article · Mar 2000
Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoprotein Article · 1 Jan 2000
In vitro inhibition of the replication of haemorrhagic septicaemia virus (VHSV) and African swine fever virus (ASFV) by extracts from marine microalgae Article · Nov 1999
Efficient formation of influenza virus-like particles: Dependence on the expression levels of viral proteins Article · 1 Jul 1999
The African Swine Fever Virus Proteins p54 and p30 Are Involved in Two Distinct Steps of Virus Attachment and Both Contribute to the Antibody-Mediated Protective Immune Response Article · Apr 1998
Blocking antibodies inhibit complete African swine fever virus neutralization Article · Jun 1997
Neutralization susceptibility of African swine fever virus is dependent on the phospholipid composition of viral particles Article · Feb 1997
High level expression of the major antigenic African swine fever virus proteins p54 and p30 in baculovirus and their potential use as diagnostic reagents Article · Feb 1997
Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization Article · Aug 1996
The structural protein p54 is essential for African swine fever virus viability Article · Feb 1996
IMPROVEMENT OF AFRICAN SWINE-FEVER VIRUS NEUTRALIZATION ASSAY USING RECOMBINANT VIRUSES EXPRESSING CHROMOGENIC MARKER GENES Article · Oct 1995
THE ACTIVITY OF SYNAPTOSOMAL CALCIUM CHANNELS IS INVERSELY CORRELATED WITH WORKING-MEMORY PERFORMANCE IN MEMORY-IMPAIRED, AGED RATS Article · Jan 1994
AGE-RELATED-CHANGES IN CALCIUM HOMEOSTATIC MECHANISMS IN SYNAPTOSOMES IN RELATION WITH WORKING-MEMORY DEFICIENCY Article · Sep 1993
PYRUVATE-DEHYDROGENASE DEPHOSPHORYLATION IN RAT-BRAIN SYNAPTOSOMES AND MITOCHONDRIA - EVIDENCE FOR A CALCIUM-MEDIATED EFFECT IN RESPONSE TO DEPOLARIZATION, AND VARIATIONS DUE TO AGING Article · Aug 1992
CONDITIONS RESTRICTING DEPOLARIZATION-DEPENDENT CALCIUM INFLUX IN SYNAPTOSOMES REVEAL A GRADED RESPONSE OF P96-DEPHOSPHORYLATION AND A TRANSIENT DEPHOSPHORYLATION OF P65 Article · Jun 1991

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