Detalle de: Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor
| Title | Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor |
| Abstract |
Antimicrobial resistance drives the need of synergistically combined powerful computational tools and experimental work to accelerate target identification and drug development. Here, we present a high-quality metabolic model of H. influenzae and show its usefulness both as a computational framework for large experimental data set contextualization and as a tool to discover condition-independent drug targets. |
| Apa Reference | López-López, N., León, D.S., de Castro, S., Díez-Martínez, R., Iglesias-Bexiga, M., Camarasa, M.J., Menéndez, M., Nogales, J. & Garmendia, J. (2022). Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor. mSystems, 7(2). 10.1128/msystems.01459-21 |
| Doi | 10.1128/msystems.01459-21 |
| Publication Date | 26 Apr 2022 |
| Publication Type | Article |
| Researcher | David San León Granado |
| Ontology | Metabolic modelling, Drug Discovery and design, Development, Drug resistance |
| Research Groups | Systems Biotechnology Group |
| Tools |