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Research Group

Detalle de: Panomics and Evolutionary Systems Microbiology (I2SYSBIO)

Title Panomics and Evolutionary Systems Microbiology (I2SYSBIO)
Description

[EN] The main research interest of the Panomics and Evolutionary Systems Microbiology group lies in understanding the molecular mechanisms of functional innovation at different levels and contexts. The evolution of novel functions is paramount to the emergence of biological complexity and ecological diversification. Understanding how innovation is generated and in which contexts is not only interesting from a basic science point of view but potentially extremely valuable in relation to health, biotechnology and agriculture. We combine theoretical and experimental research in a multidisciplinary way. In the theoretical part we look for adaptive signatures left in the genomes over millions of years, and create software where necessary. In the experimental part of our research we evolve microorganisms to observe evolution in the act, while applying different stressors resembling environmental challenges. Using the yeast Saccharomyces cerevisiae as model for oxidative stress, we determine phenotypic changes, and use it as model to test several bioactive compounds.

[ES] El principal interés de investigación del grupo de Microbiología de Sistemas Evolutivos y Panómica, ubicado en el I2SysBio, radica en comprender los mecanismos moleculares de la innovación funcional en diferentes niveles y contextos. La evolución de nuevas funciones es fundamental para el surgimiento de la complejidad biológica y la diversificación ecológica. Comprender cómo se genera la innovación y en qué contextos no solo es interesante desde el punto de vista de la ciencia básica, sino que también es potencialmente muy valioso en relación con la salud, la biotecnología y la agricultura. Combinamos la investigación teórica y experimental de forma multidisciplinar. En la parte teórica, buscamos firmas adaptativas dejadas en los genomas a lo largo de millones de años y creamos software cuando es necesario. En la parte experimental de nuestra investigación, hacemos evolucionar microorganismos para observar la evolución en el acto.

Home Page https://www.i2sysbio.es/groups/22/
Contact Email Christina.Toft@csic.es
Collaborating Companies
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Patents
Hpc Resources
Institution I2SYSBIO
Ontology Omics, Computational Methods, Resources, Transcriptomics, Data Analysis, Bioinformatics Software and Tools, Analysis packages (R, Python, etc.), Data Visualization, Applications of Computational Biology, Model organisms, Genomics, Systems Biology, Molecular evolution, Sequence analysis, Comparative Genomics
Tools GWideCodeML
Service Units
Research Lines Biotechnology and Systems Biology of Micro-organisms in Agricultural Sciences, Modeling life responses to environmental crises, Fighting dysbiosis, Biosolutions for feeding in a changing planet
Funded Projects Conexión CSIC en Biología Computacional y Bioinformática (BCBHub), HAVEN: The interplay between host aging and virus evolution: an evolutionary integrative systems biology approach
Selected Publications
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Researchers Christina Toft, Beatriz Sabater-Muñoz

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