Detalle de: Fish Immunology and Pathology
| Title | Fish Immunology and Pathology |
| Description |
The group's main objective is to understand the regulatory mechanisms of the immune response to infectious agents in fish (viruses, bacteria, or parasites). Our research aims to utilize this improved understanding of resistance mechanisms in fish, specially of how adaptive immune responses are orchestrated, to design more effective vaccines, novel molecular adjuvants, or control strategies based on immunomodulation. Specifically, an important part of our research efforts are focused at phenotypically and functionally characterizing B lymphocytes, which are responsible for antibody production, and establishing the immune role of the different types of fish antibodies (immunoglobulins). We also study the functions of cytokines, molecules that mediate the immune response between cells. In collaboration with different vaccine companies, we also try to optimize novel vaccination strategies, specially oral vaccines, that could be delivered to the fish more efficiently than the currently available injection vaccines. |
| Home Page | https://www.csic.es/en/investigation/research-groups/fish-immunology-and-pathology |
| Contact Email | tafalla@inia.csic.es |
| Collaborating Companies | |
| Spin Off | |
| Patents | Use of a vector encoding trout interleukin 8 as an immunostimulant or vaccine adjuvant in fish. Oral delivery of DNA using alginate-coated liposomes (Nouveaux liposomes de vaccination génique). Use of PACAP for treating viral infections in aquatic organisms. Methods of blocking TNF family cytokines for treatment of inflammatory diseases in fish. |
| Hpc Resources | DRAGO |
| Institution | INIA |
| Ontology | Omics, Transcriptomics, RNA Sequencing (RNA-seq), Analysis packages (R, Python, etc.), Functional annotation, Expression Profiling, Single-cell omics, Single-cell (scRNA-seq), Animal health |
| Tools | |
| Service Units | |
| Research Lines | Understand how the adaptive immune system is regulated in teleost fish, Optimize novel vaccination strategies for aquaculture, BCR and TCR repertoire analysis |
| Funded Projects | Respuestas IgM e IgD en mucosas de peces: cinética, interacciones, respuestas secundarias, memoria y quimiotaxis, European Partnership Animal health and Welfare, Green innovation strategies for animal health management: towards sustainable Aquaculture (GRINNAQUA), Blocking BAFF signaling to treat proliferative kidney disease (PKD) in trout (PKDcontrol), Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity, Teleost B lymphocytes, the equivalent of mammalian B1 lymphocytes?, Papel inmunomodulador y microbicida de las quimioquinas en trucha arcoiris |
| Selected Publications |
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| Researchers | Carolina Tafalla Piñeiro, Pablo Jiménez Barrios, Aitor Arrogante López |