Jose C. Reyes
Epigenetics and Gene Expression · CABIMER
Biography
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Dr. Reyes have a PhD in Biological Sciences from the University of Seville. He did a PhD at the Institute of Plant Biochemistry and Photosynthesis (IBVF, Seville) between 1990 and 1994. After that, he did a postdoctoral stay of 3.5 years at the Pasteur Institute in Paris in Moshe Yaniv's laboratory, where he studied the SWI/SNF chromatin remodeling complexes in mammals. In 1998 he did a stay as visiting scientist at the National Institute of Health in Bethesda (USA) in Gordon Hager's laboratory, where he investigated the nuclear dynamics of GFP-fused chromatin remodelers. In 2000, he obtained a position at the CSIC and started his own laboratory at the IBVF where he began a line of research on chromatin remodeling in the model plant Arabidopsis thaliana. They were the first to describe and characterize the existence and functions of the SWI/SNF and SWR1 complexes in plants. In 2002, he obtained the prize for Young Investigators from the Seville Academy of Sciences. In 2006, he transferred his laboratory to the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER, Seville), of which he has been Vice Director from July 2016 to December 2020, and currently he is Director of the Department of Genome Biology. Dr. Reyes has published 80 papers, most of them in prestigious international journals. He is among the top 2% of the most cited world scientists of all scientific fields in the ranking by Meta-Research Innovation Center (METRICS) at Stanford University (Editions 2019, 2020 and 2021) (5300 Scopus cites, 7750 Google Scholar cites), which gives an idea of the international impact of his research. |
Profile
| Institution | CABIMER |
| Position | Research Scientist (CSIC), Principal Investigator |
| Home page | https://www.cabimer.es/en/research-groups/epigenetics-and-gene-expression/ |
| Contact email | jose.reyes@cabimer.es |
| ORCID | 0000-0002-8042-5142 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | CODfinder |
| BCB Services |
Research
Research topics
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Projects, networks, transfer & teaching
Research networks
National
- AEI-MICINN Genomic Regulation Network (R2G2).
- CSIC Cancer-Connection network.
Funded projects 4
Publications 85 entries
- The SUMO isopeptidase activity of SENP7 can sustain the expression of developmental genes but not a repressive state on chromosome X Preprint · 6 Aug 2026
- FGFR1 drives metabolic adaptation associated with temozolomide resistance in glioblastoma Article · Aug 2026
- HMCES corrupts replication fork stability during base excision repair in homologous recombination-deficient cells Article · 28 Mar 2025
- Author Correction: Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging Article · 12 Feb 2025
- SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition Article · 27 Jul 2024
View all (80 more)
- Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas Article · 6 Mar 2024
- SWI/SNF-dependent genes are defined by their chromatin landscape Article · Mar 2024
- Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging Article · 8 Mar 2023
- SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer Article · Nov 2022
- The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways Article · 16 Sep 2022
- TGF-β-Upregulated Lnc-Nr6a1 Acts as a Reservoir of miR-181 and Mediates Assembly of a Glycolytic Complex Article · 15 Sep 2022
- Serum-dependent recruitment of the chromatin remodeler CHD8 to promoters is mediated by the ERK-ELK pathway Preprint · 9 Sep 2022
- Co-transcriptional splicing efficiency is a gene-specific feature that can be regulated by TGFβ Article · 28 Mar 2022
- Deciphering CHFR Role in Pancreatic Ductal Adenocarcinoma Article · 19 Nov 2021
- The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity Article · 2021
- TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains Article · 3 Dec 2020
- Human prefoldin modulates co-transcriptional pre-mRNA splicing Preprint · 15 Jun 2020
- Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer Article · 24 Apr 2020
- The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes Article · 18 Jul 2019
- Dissecting the Brain/Islet Axis in Metabesity Article · 8 May 2019
- TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells Article · 31 Jan 2019
- The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity Article · 15 Feb 2018
- Lineage specific transcription factors and epigenetic regulators mediate TGFβ-dependent enhancer activation Article · 9 Feb 2018
- High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer Article · 1 Feb 2018
- Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage Article · 27 Nov 2017
- Analysis of the relationship between coexpression domains and chromatin 3D organization Software · 13 Sep 2017
- Histone availability as a strategy to control gene expression Article · 21 Jul 2016
- Chromatin structure and pre-mRNA processing work together Article · 30 Mar 2016
- Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing Article · 17 Nov 2015
- The Chromatin Remodeler CHD8 Is Required for Activation of Progesterone Receptor-Dependent Enhancers Article · 20 Apr 2015
- A positioned +1 nucleosome enhances promoter-proximal pausing Article · 3 Mar 2015
- HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition Article · 2 Feb 2015
- The Many Faces of Plant SWI/SNF Complex Article · Mar 2014
- The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes Article · 20 Nov 2013
- Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis Article · 15 Jul 2013
- The CopRS Two-Component System Is Responsible for Resistance to Copper in the Cyanobacterium Synechocystis sp. PCC 6803 Article · 19 Jun 2012
- p21 as a Transcriptional Co-Repressor of S-Phase and Mitotic Control Genes Article · 25 May 2012
- Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex Article · 8 May 2012
- To cross or not to cross the nucleosome, that is the elongation question… Article · May 2011
- Brahma Is Required for Proper Expression of the Floral Repressor FLC in Arabidopsis Article · 21 Mar 2011
- BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivo Article · 10 Sep 2010
- CHD3 Proteins and Polycomb Group Proteins Antagonistically Determine Cell Identity in Arabidopsis Article · 14 Aug 2009
- The Beauty of Being a Variant: H2A.Z and the SWR1 Complex in Plants Article · Jul 2009
- The Glutathione/Glutaredoxin System Is Essential for Arsenate Reduction in Synechocystis sp. Strain PCC 6803 Article · Jun 2009
- SUMO association with repressor complexes, emerging routes for transcriptional control Article · Jun 2009
- The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene Article · 2 Mar 2009
- The PHD Domain of Plant PIAS Proteins Mediates Sumoylation of Bromodomain GTE Proteins Article · Aug 2008
- The Arabidopsis BRAHMA Chromatin-Remodeling ATPase Is Involved in Repression of Seed Maturation Genes in Leaves Article · 28 May 2008
- Histone H2A.Z and homologues of components of the SWR1 complex are required to control immunity in Arabidopsis Article · 6 Nov 2007
- A Nucleosome Interaction Module Is Required for Normal Function of Arabidopsis thaliana BRAHMA Article · Oct 2007
- The ammonium‐inactivated cyanobacterial glutamine synthetase I is reactivated in vivo by a mechanism involving proteolytic removal of its inactivating factors Article · 16 Jun 2007
- SEF, a New Protein Required for Flowering Repression in Arabidopsis, Interacts with PIE1 and ARP6 Article · 1 Dec 2006
- The putative SWI/SNF complex subunit BRAHMA activates flower homeotic genes in Arabidopsis thaliana Article · 15 Jul 2006
- Chromatin modifiers that control plant development Article · Feb 2006
- Ammonium assimilation in cyanobacteria Article · Feb 2005
- The Arabidopsis thaliana SNF2 homolog AtBRM controls shoot development and flowering Article · 15 Oct 2004
- The GATA Family of Transcription Factors in Arabidopsis and Rice Article · 1 Apr 2004
- Arsenic Sensing and Resistance System in the Cyanobacterium Synechocystis sp. Strain PCC 6803 Article · 15 Sep 2003
- The inactivating factor of glutamine synthetase, IF7, is a “natively unfolded” protein Article · Jul 2003
- Diverse functions of Polycomb group proteins during plant development Article · Feb 2003
- Chromatin-Remodeling and Memory Factors. New Regulators of Plant Development Article · 1 Nov 2002
- A two‐component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803 Article · Jan 2002
- Cyanobacteria Perceive Nitrogen Status by Sensing Intracellular 2-Oxoglutarate Levels Article · Oct 2001
- The Glucocorticoid Receptor Interacting Protein 1 (GRIP1) Localizes in Discrete Nuclear Foci That Associate with ND10 Bodies and Are Enriched in Components of the 26S Proteasome Article · 1 Apr 2001
- PML and COP1 – two proteins with much in common Article · Jan 2001
- A Gene Cluster Involved in Metal Homeostasis in the Cyanobacterium Synechocystis sp. Strain PCC 6803 Article · 15 Mar 2000
- NtcA represses transcription of gifA and gifB , genes that encode inhibitors of glutamine synthetase type I from Synechocystis sp. PCC 6803 Article · Mar 2000
- Light-Dependent Regulation of Cyanobacterial Phytochrome Expression Article · Jan 2000
- Tracking Components of the Transcription Apparatus in Living Cells Article · Nov 1999
- Glutamine synthetase inactivation by protein–protein interaction Article · 22 Jun 1999
- The Presence of Glutamate Dehydrogenase Is a Selective Advantage for the Cyanobacterium Synechocystis sp. Strain PCC 6803 under Nonexponential Growth Conditions Article · Feb 1999
- Altered control of cellular proliferation in the absence of mammalian brahma (SNF2α) Article · 1 Dec 1998
- ras transformation is associated with decreased expression of the brm/SNF2α ATPase from the mammalian SWI–SNF complex Article · 1 Jan 1998
- Components of the Human SWI/SNF Complex Are Enriched in Active Chromatin and Are Associated with the Nuclear Matrix Article · 21 Apr 1997
- Transcription of glutamine synthetase genes (glnA and glnN) from the cyanobacterium Synechocystis sp. strain PCC 6803 is differently regulated in response to nitrogen availability Article · Apr 1997
- Purification and Characterization of A New Type of Glutamine Synthetase from Cyanobacteria Article · Feb 1997
- The hbrm and BRG‐1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. Article · 1 Jul 1996
- The NADP+-isocitrate dehydrogenase gene (icd) is nitrogen regulated in cyanobacteria Article · Jul 1996
- A novel mechanism of glutamine synthetase inactivation by ammonium in the cyanobacterium Synechocystis sp . PCC 6803. Involvement of an inactivating protein Article · 19 Jun 1995
- The NADP-glutamate dehydrogenase of the cyanobacterium Synechocystis 6803: cloning, transcriptional analysis and disruption of the gdhA gene Article · Apr 1995
- Electron transport controls transcription of the glutamine synthetase gene (glnA) from the cyanobacterium Synechocystis sp. PCC 6803 Article · Feb 1995
- A mutant lacking the glutamine synthetase gene (glnA) is impaired in the regulation of the nitrate assimilation system in the cyanobacterium Synechocystis sp. strain PCC 6803 Article · Dec 1994
- A new type of glutamine synthetase in cyanobacteria: the protein encoded by the glnN gene supports nitrogen assimilation in Synechocystis sp. strain PCC 6803 Article · Mar 1994
- Effect of Glucose Utilization on Nitrite Excretion by the Unicellular Cyanobacterium Synechocystis sp. Strain PCC 6803 Article · Sep 1993
- Chromatin Remodeling and Histone Variants in Transcriptional Regulation and in Maintaining DNA Methylation Book / chapter
