Alfonso Benítez Páez
Bioinformatics, Computational Biology and Data Science · IATA
Biography
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Dr Alfonso Benítez Páez, has a BSc degree in Biology, with MSc degree in Biochemistry, and a Diploma in Biotechnology. He received his PhD degree in Molecular Biology in June 2010 (Universidad Autónoma de Madrid). During his PhD training under the supervision of Dr Mª Eugenia Armengod (CIPF, Valencia) and collaborative work with Dr Toni Gabaldón (CRG, Barcelona), Dr Benítez acquired notable expertise in bacterial genomics, molecular biology, and recombinant protein analyses fundamental to describe for the first time functions of the TrmL and RlmN RNA E. coli orphan methylases. His postdoctoral training started in the Dr Alex Mira laboratory (FISABIO-CSISP, Valencia), where he studied human microbiota and its influence on human health. Later on, he enrolled in Prof Yolanda Sanz's laboratory (IATA-CSIC, Paterna) to study the intestinal microbiota and to unveil the host-diet-microbe interactions. Dr Benítez has completed short- and mid-term fellowships in excellence centers such as the University of Bolonia (Prof Patrizia Brigidi's group, Bolonia, Italia, 2017) and the European Molecular Biology Laboratory - EMBL (Dr Georg Zeller's group, Heidelberg, Germany, 2018), and to develop three microbiota-based licensed patents. Dr Benítez has envisioned and led outstanding research projects such as developing new molecular protocols for the characterization of complex microbial communities based on cutting-edge sequencing platforms and implementing multi-omics analysis in random clinical trials to decipher diet-host-microbiota interactions in obesity and metabolic impairment. After almost ten years of postdoctoral experience and an excellent publication track record, Dr Benítez was granted with a "Miguel Servet" competitive contract (ISCIII) on the 2019 call to work as Junior Group Leader R3 at the CIPF for five years. From 2020 to 2023 he led the CIPF Host-Microbe Interactions in Metabolic Health laboratory performing advanced investigation in the human gut microbiome. His scientific career is already recognized overseas because of the regular invitation to review manuscripts in top-ranked journals specialized in nutrition, gastroenterology and microbiome research (e.g. Microbiome, Gut, Clinical Nutrition, Gut Microbes, Science Advances) and because of his membership as Associate Editor of Frontiers in Microbiology and Frontiers in Nutrition journals. Dr Benítez has also been committed to training and formation of young investigators to complete their Master (10 trainees supervised) or PhD thesis (3 trainees supervised). Dr Benítez possesses the I3 certificate (I3/2021/0034) by the Spanish Ministry of Universities and the AEI (Agencia Estatal de Investigación). Furthermore, Dr Benítez Páez holds the following credentials: Assistant Professor Doctor (PAD), Contracted Professor Doctor (PCD), and Private University Professor (PUP) by ANECA agency (November 2020), and three Research Six-year period certifications (2007-2012, 2013-2018, 2019-2024) by ANECA Spanish agency. Dr Benítez has a permanent position (Tenured Scientist) at the IATA-CSIC Severo-Ochoa Excellence Center (from 2024 onward). |
Profile
| Institution | IATA |
| Position | Tenured Scientist (Científico Titular) - Group Leader, IATA-CSIC |
| Home page | https://www.researchgate.net/profile/Alfonso-Benitez-Paez |
| Contact email | abenitez@iata.csic.es |
| ORCID | 0000-0001-5707-4340 |
BCB Hub
| BCB Committee | Outreach, Talent attraction and training |
| BCB Tools | microSTASIS |
| BCB Services |
Research
Research topics
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Research lines
Projects, networks, transfer & teaching
Research networks
National
- Red de Investigación Microbiota Aplicada a la Salud Humana (MIdAS). RED2022-134934T. Ministerio de Ciencia, Innovación y Universidades.
- Conexión MICROBIOMA CSIC.
- Conexión GENOMC CSIC
Industry & knowledge transfer
Collaborating companies
- Arla Food
- Agrifiber
Patents
- 1. (Patent) Authors: Sanz Y.; Benítez-Páez, A; Gómez del Pulgar, Eva Mª; Francés, R.; Gómez-Hurtado, I.; Piñero, Paula; Juanola, Oriol. Title: “Bifidobacterium longum sub. infantis strain and its use” Request No.: P201830961. Request date: 05-Oct-2018. Protection issue: PCT1641.1407 (04/Dec/2019). Institutional ownership: CSIC, FISABIO, UMH, CIBER, Spain.
- 2. (Patent) Authors: Sanz Y; López-Almela, I; Gómez del Pulgar, Eva Mª; Benítez-Páez, A; Romaní-Pérez, M. Title: “Phascolarctobacterium faecium for prevention and treatment of obesity and comorbidities” Request No.: P201831166. Request date: 30-Nov-2018. Request issue: PCT/ES2019/070821 (02/Dec/2019). Institutional ownership: CSIC, Spain.
- 3. (Patent) Authors: Sanz Y; López-Almela, I; Gómez del Pulgar, Eva Mª; Benítez-Páez, A; Romaní-Pérez, M. Title: “Bacteria Hodemanella sp. and its use” Request No.: P201831282. Request date: 26-Dec-2018. Request issue: PCT/ES2019/070882 (24/Dec/2019). Institutional ownership: CSIC, Spain.
Teaching
Master programs
- Master in Biomedical Biotechnology - Universidad Politécnica de Valencia
Funded projects 3
- Functional mimicry of the human dipeptidyl peptidase-4 activity by the gut microbes and dietary strategies for its inhibition – MIMICROBES
- Identification of genetic and metabolic components of the gut microbiota and dietary strategies for preventing non-communicable diseases.
- Mimetismo funcional de la actividad dipeptidil peptidasa 4 por la microbiota intestinal humana y estrategias dietéticas para su inhibición
Publications 73 entries
- Valorization of orange peel by-products via ultrasound-pretreated enzymatic extraction of soluble dietary fiber: Structural and functional characterization Article · 1 Sep 2026
- Multimodal neuroimaging–microbiota integration identifies Akkermansia as a modulator of alcohol-induced gut–liver–brain pathology Preprint · 7 Aug 2026
- Phascolarctobacterium faecium reduces food intake via PYY signaling, contributing to the mitigation of body weight gain in diet-induced obese mice Article · 21 Jan 2026
- Dietary patterns drive loss of fiber-foraging species in the celiac disease patients gut microbiota compared to first-degree relatives Article · 8 Oct 2024
- Extracellular vesicles from mesenchymal stem cells alter gut microbiota and improve neuroinflammation and motor impairment in rats with mild liver damage Article · Oct 2024
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- Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation Article · 3 Jul 2024
- Bacteroides uniformis CECT 7771 requires adaptive immunity to improve glucose tolerance but not to prevent body weight gain in diet-induced obese mice Article · 6 Jun 2024
- Comparative Binding Study of Gliptins to Bacterial DPP4-like Enzymes for the Treatment of Type 2 Diabetes Mellitus (T2DM) Article · 25 May 2024
- Editorial: Contribution of the maternal microbiome to offspring health Article · 19 Jun 2023
- Intestinal microbiota is modified in pediatric food protein–induced enterocolitis syndrome Article · Nov 2022
- The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets Article · 23 Sep 2022
- Species- and strain-level assessment using rrn long-amplicons suggests donor’s influence on gut microbial transference via fecal transplants in metabolic syndrome subjects Article · 23 May 2022
- Assessment of human microbiota stability across longitudinal samples using iteratively growing-partitioned clustering Software · 28 Feb 2022
- Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome Article · 28 Jan 2022
- Editorial: Remodeling Composition and Function of Microbiome by Dietary Strategies-Functional Foods Perspective Article · 30 Nov 2021
- Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat Article · 6 Jul 2021
- Holdemanella biformis improves glucose tolerance and regulates GLP‐1 signaling in obese mice Article · 18 Jun 2021
- Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice Article · 3 Jun 2021
- Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men Article · 9 Mar 2021
- Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice Article · Jan 2021
- Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome Article · Dec 2020
- Microbial enterotypes beyond genus level: Bacteroides species as a predictive biomarker for weight change upon controlled intervention with arabinoxylan oligosaccharides in overweight subjects Article · 9 Nov 2020
- Study protocol of the Bergen brain-gut-microbiota-axis study A prospective case-report characterization and dietary intervention study to evaluate the effects of microbiota alterations on cognition and anatomical and functional brain connectivity in patients with irritable bowel syndrome Article · 11 Sep 2020
- Breast-Milk Microbiota Linked to Celiac Disease Development in Children: A Pilot Study From the PreventCD Cohort Article · 23 Jun 2020
- Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening Article · 28 Apr 2020
- Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants Article · 20 Feb 2020
- Nutritional interest of dietary fiber and prebiotics in obesity: Lessons from the MyNewGut consortium Article · Feb 2020
- Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis Article · 10 Jan 2020
- Arabinoxylan oligosaccharides and polyunsaturated fatty acid effects on gut microbiota and metabolic markers in overweight individuals with signs of metabolic syndrome: A randomized cross-over trial Article · Jan 2020
- Dietary fat, the gut microbiota, and metabolic health – a systematic review conducted within the MyNewGut project Article · Dec 2019
- The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention Article · 11 Oct 2019
- A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans Article · 27 Aug 2019
- #EUROmicroMOOC: using Twitter to share trends in Microbiology worldwide Article · 1 Jun 2019
- Agarose-based freeze-dried capsules prepared by the oil-induced biphasic hydrogel particle formation approach for the protection of sensitive probiotic bacteria Article · Feb 2019
- Pre-obese children’s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity Article · 7 Dec 2018
- Towards microbiome-informed dietary recommendations for promoting metabolic and mental health: Opinion papers of the MyNewGut project Article · Dec 2018
- Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children Article · 24 Sep 2018
- Bacillus subtilis exhibits MnmC-like tRNA modification activities Article · 2 Sep 2018
- The potential role of the Dipeptidyl peptidase-4-like activity from the gut microbiota on the Host Health Article · 22 Aug 2018
- Plant sterols and human gut microbiota relationship: An in vitro colonic fermentation study Article · May 2018
- Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study Article · 19 Apr 2018
- Gut microbiota trajectory in early life may predict development of celiac disease Article · 20 Feb 2018
- Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice. Article · Oct 2017
- The glycolytic versatility of Bacteroides uniformis CECT 7771 and Its genome response to oligo and polysaccharides Article · 25 Aug 2017
- Multi-locus and long amplicon sequencing approach to study microbial diversity at species level using the MinION™ portable nanopore sequencer Article · 12 Jun 2017
- List of Contributors Book / chapter · 2017
- From Bacterial Genomics to Human Health Book / chapter · 2017
- Impact of dietary fiber and fat on gut microbiota re-modeling and metabolic health Article · Nov 2016
- Gut microbiota, diet, and obesity-related disorders-the good, the bad, and the future challenges Article · 20 Sep 2016
- Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice Article · 7 Jul 2016
- Genome Structure of the Symbiont Bifidobacterium pseudocatenulatum CECT 7765 and Gene Expression Profiling in Response to Lactulose-Derived Oligosaccharides Article · 29 Apr 2016
- Species-level resolution of 16S rRNA gene amplicons sequenced through the MinION (TM) portable nanopore sequencer Article · 28 Jan 2016
- Pangenome-wide and molecular evolution analyses of the Pseudomonas aeruginosa species Article · 12 Jan 2016
- Targeting the Microbiota: Considerations for Developing Probiotics as Functional Foods Book / chapter · 2016
- Development of Quantitative Proteomics Using iTRAQ Based on the Immunological Response of Galleria mellonella Larvae Challenged with Fusarium oxysporum Microconidia Article · 7 Nov 2014
- Evolutionary and sequence-based relationships in bacterial AdoMet-dependent non-coding RNA methyltransferases Article · 10 Jul 2014
- Streptococcus dentisani sp nov., a novel member of the mitis group Article · 1 Jan 2014
- iTRAQ, the high throughput data analysis of proteins to understand immunologic expression in insect Book / chapter · 2014
- Microbiota diversity and gene expression dynamics in human oral biofilms Article · 2014
- Impairing methylations at ribosome RNA, a point mutation-dependent strategy for aminoglycoside resistance: The rsmG case Article · 29 Aug 2013
- Detection of Transient Bacteraemia following Dental Extractions by 16S rDNA Pyrosequencing: A Pilot Study Article · 4 Mar 2013
- The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy Article · 13 Aug 2012
- Enzymology of tRNA modification in the bacterial MnmEG pathway Article · Jul 2012
- Regulation of expression and catalytic activity of Escherichia coli RsmG methyltransferase Article · 15 Feb 2012
- A practical guide for the computational selection of residues to be experimentally characterized in protein families Article · 19 Sep 2011
- YibK is the 2 '-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors Article · 20 Sep 2010
- Bioinformatics in Colombia: State of the art and perspectives,Bioinformática en Colombia: Presente y futuro de la investigación biocomputacional Article · 4 Aug 2010
- Structure-Function Analysis of Escherichia coli MnmG (GidA), a Highly Conserved tRNA-Modifying Enzyme Article · 15 Dec 2009
- Considerations to Improve Functional Annotations in Biological Databases Article · Dec 2009
- Population analysis from 12 microsatellite loci reveled by silver stain and assisted by computer software Article · Apr 2004
- Allelic frequencies at 12 STR loci in Colombian population Article · Sep 2003
- Results of the GEP-ISFG collaborative study on two Y-STRs tetraplexes: GEPY I (DYS461, GATA C4, DYS437 and DYS438) and GEPY II (DYS460, GATA A10, GATA H4 and DYS439) Article · Aug 2003
- Population data of new Y-chromosome STRs GATA C4, DYS438, DYS437, GATA A7.2, GATA H4, DYS439 and GATA A10 in males from Colombia Article · Aug 2003
