María de Toro
Biography
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I am a chemist with a PhD in Biochemistry and a specialization in bioinformatics and clinical genetics. My professional journey began at the University of Cantabria, where I joined the European project PLASWIRES, immersing myself in bioinformatics and specializing in genomic and metagenomic analysis of bacterial communities. Since 2016, I have been leading the Genomics and Bioinformatics Platform at CIBIR, where I combine my expertise in bioinformatics, machine learning and clinical genomics with managing a core facility. I currently serve as a board member (vocal) of the Clinical Bioinformatics Working Group within the Spanish Society of Bioinformatics and Computational Biology (SEBiBC). Throughout my career, I have participated in more than 20 national and international projects, focusing on the role of mobile genetic elements in antibiotic resistance, pathogen monitoring using NGS, and the application of sequencing techniques to viticulture and food safety. I am currently involved in projects such as Eco2Wine (developing sustainable winemaking practices), CRINGENES (improving neonatal screening for rare diseases) and RELECOV 2.0 (a network for monitoring respiratory pathogens using whole-genome sequencing). During the COVID-19 pandemic, I led SARS-CoV-2 sequencing efforts in La Rioja, transforming our platform into a regional reference node for pathogen sequencing. Beyond research, I have taught as a professor in the Bioinformatics Master's programme at VIU and supervised master's theses. I am also passionate about science communication, taking part in initiatives like Pint of Science and organizing workshops on genomics and bioinformatics. |
Profile
| Institution | CIBIR |
| Position | Head of the Genomics and Bioinformatics Core Facility, CIBIR (La Rioja) |
| Home page | https://es.linkedin.com/in/mariadetoro |
| Contact email | mthernando@riojasalud.es |
| ORCID | 0000-0003-3329-0203 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | |
| BCB Services | Genomics and Bioinformatics Core Facility at CIBIR |
Research
Research topics
Research lines
None
Projects, networks, transfer & teaching
Research networks
National
- SEBiBC - Spanish Society of Bioinformatics and Computational Biology (board member of the Clinical Bioinformatics Working Group, since 2026)
- RELECOV 2.0 - Spanish network for the genomic surveillance of respiratory pathogens
Teaching
Master programs
- Master in Bioinformatics - Universidad Internacional de Valencia (VIU) (professor, 2021-2024)
Funded projects 5
- BIOINFORMÁTICA, ANÁLISIS DE DATOS Y MODELIZACIÓN PARA EL AVANCE DE LA VITIVINICULTURA
- Engineering multicellular biocircuits: programming cell-cell communication using plasmids as wires
- Natural microbial interactions in winemaking-associated ecosystems as a tool to foster wine innovation
- CrinGenES: genomic newborn screening for rare diseases
View all (1 more)
Publications 72 entries
- IGF1R deficiency mitigates acute lung injury by promoting anti-inflammatory transcriptional profiles Article · 22 Oct 2025
- Metabarcoding-based characterization of soil nematode communities to assess soil health in viticulture Article · Jul 2025
- Interplay between bacterial clones and plasmids in the spread of blaSHV-12- and blaCTX-M-14-carrying Escherichia coli from the livestock environment Article · Jun 2025
- Development of human targeted extracellular vesicles loaded with shRNA minicircles to prevent parkinsonian pathology Article · 26 May 2025
- Vineyard mycobiota shows a local and long-term response to the organic mulches application Article · Apr 2025
View all (67 more)
- Co-occurrence of entomopathogenic nematodes and earthworms enhances enduring biocontrol activity and microbial diversity in a naturalized plant-soil system Article · Jan 2025
- Seed-mediated vertical transmission of Pantoea core endophytes Article · Jan 2025
- Transcriptomics of acute injured lungs reveals IGF1R action on DNA damage response, metabolic reprogramming, mitochondrial homeostasis and epigenetics Preprint · 14 Oct 2024
- Organic mulches in grapevine shape bacterial communities in specific vintage and location Article · Sep 2024
- Unprocessed snRNAs Are a Prognostic Biomarker and Correlate with a Poorer Prognosis in Colorectal Cancer Article · 26 Jun 2024
- The most exposed regions of SARS-CoV-2 structural proteins are subject to strong positive selection and gene overlap may locally modify this behavior Article · 23 Jan 2024
- Spread of Pseudomonas aeruginosa ST274 Clone in Different Niches: Resistome, Virulome, and Phylogenetic Relationship Article · 24 Oct 2023
- Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome Article · 31 Aug 2023
- Genomic Analysis of Bacteriocin-Producing Staphylococci: High Prevalence of Lanthipeptides and the Micrococcin P1 Biosynthetic Gene Clusters Article · 26 Aug 2023
- Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network Article · 10 May 2023
- Spread of blaCTX-M-9 and Other Clinically Relevant Resistance Genes, Such as mcr-9 and qnrA1, Driven by IncHI2-ST1 Plasmids in Clinical Isolates of Monophasic Salmonella enterica Serovar Typhimurium ST34 Article · 9 Mar 2023
- High-risk international clones ST66, ST171 and ST78 of Enterobacter cloacae complex causing blood stream infections in Spain and carrying blaOXA-48 with or without mcr-9 Article · Feb 2023
- Antibiotic removal does not affect cecal microbiota balance and productive parameters in LP robust rabbit line Article · 7 Nov 2022
- Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions Article · 8 Sep 2022
- Detection of the optrA Gene Among Polyclonal Linezolid-Susceptible Isolates of Enterococcus faecalis Recovered from Community Patients Article · 1 Jul 2022
- Integrase Inhibitors Partially Restore Bacterial Translocation, Inflammation and Gut Permeability Induced by HIV Infection: Impact on Gut Microbiota Article · 26 May 2022
- Colistin Resistance in Monophasic Isolates of Salmonella enterica ST34 Collected From Meat-Derived Products in Spain, With or Without CMY-2 Co-production Article · 6 Jan 2022
- ExplorePipolin: reconstruction and annotation of piPolB-encoding bacterial mobile elements from draft genomes Article · 1 Jan 2022
- What Does 16S rRNA Gene-Targeted Next Generation Sequencing Contribute to the Study of Infective Endocarditis in Heart-Valve Tissue? Article · 29 Dec 2021
- Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals Article · 5 Oct 2021
- Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium Article · 1 Jun 2021
- Oral subchronic exposure to the mycotoxin ochratoxin A induces key pathological features of Parkinson's disease in mice six months after the end of the treatment Article · Jun 2021
- Genomic Insights into Drug Resistance and Virulence Platforms, CRISPR-Cas Systems and Phylogeny of Commensal E. coli from Wildlife Article · 5 May 2021
- Assessment of Microbiota Modulation in Poultry to Combat Infectious Diseases Article · 26 Feb 2021
- Oral Sub-Chronic Ochratoxin a Exposure Induces Gut Microbiota Alterations in Mice Article · 1 Feb 2021
- Unraveling the emergence and population diversity of Listeria monocytogenes in a newly built meat facility through whole genome sequencing Article · Feb 2021
- Whole Genome Analysis of Environmental Pseudomonas mendocina Strains: Virulence Mechanisms and Phylogeny Article · 19 Jan 2021
- Applying Genomics to Track Antimicrobial Resistance in the Food Chain Book / chapter · 2021
- Phenotypic and transcriptional analysis of Saccharomyces cerevisiae during wine fermentation in response to nitrogen nutrition and co-inoculation with Torulaspora delbrueckii Article · Nov 2020
- Molecular Characteristics of Extraintestinal Pathogenic E. coli (ExPEC), Uropathogenic E. coli (UPEC), and Multidrug Resistant E. coli Isolated from Healthy Dogs in Spain. Whole Genome Sequencing of Canine ST372 Isolates and Comparison with Human Isolates Causing Extraintestinal Infections Article · 31 Oct 2020
- Fast and Slow-Growing Management Systems: Characterisation of Broiler Caecal Microbiota Development throughout the Growing Period Article · 12 Aug 2020
- Holistic assessment of the microbiome dynamics in the substrates used for commercial champignon ( Agaricus bisporus ) cultivation Article · 27 Jul 2020
- High diversity and variability of pipolins among a wide range of pathogenic Escherichia coli strains Article · 27 Jul 2020
- Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids Article · 17 Jul 2020
- Antimicrobial resistance and virulence of Pseudomonas spp. among healthy animals: concern about exolysin ExlA detection Article · 15 Jul 2020
- Autologous fecal transplantation from a lean state potentiates caloric restriction effects on body weight and adiposity in obese mice Article · 10 Jun 2020
- Selection for Antimicrobial Resistance in Foodborne Pathogens through Exposure to UV Light and Nonthermal Atmospheric Plasma Decontamination Techniques Article · 17 Apr 2020
- Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B Article · 24 Mar 2020
- Antimicrobianos, resistencia antibacteriana y salud sostenible Article · 2020
- Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology Article · Dec 2019
- Genomic Characterization of Prevalent mcr-1, mcr-4, and mcr-5 Escherichia coli Within Swine Enteric Colibacillosis in Spain Article · 1 Nov 2019
- Plasmid Reconstruction from Next-Gen Data: A Detailed Protocol for the Use of PLACNETw for the Reconstruction of Plasmids from WGS Datasets Book / chapter · 5 Oct 2019
- Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development Article · 16 Sep 2019
- Casing microbiome dynamics during button mushroom cultivation: implications for dry and wet bubble diseases Article · 1 Jun 2019
- Exploring the bacteriome in anthropophilic ticks: To investigate the vectors for diagnosis Article · 19 Mar 2019
- Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes Article · 26 Feb 2019
- Effect of the diet type and temperature on the C. elegans transcriptome Article · 21 Dec 2017
- Whole genome sequencing, molecular typing and in vivo virulence of OXA-48-producing Escherichia coli isolates including ST131 H30-Rx, H22 and H41 subclones Article · 21 Sep 2017
- PLACNETw: a web-based tool for plasmid reconstruction from bacterial genomes Article · 21 Jul 2017
- Comparative Genomics of the Conjugation Region of F-like Plasmids: Five Shades of F Article · 10 Nov 2016
- Impacts of experimentally induced and clinically acquired quinolone resistance on the membrane and intracellular subproteomes of Salmonella Typhimurium DT104B Article · Aug 2016
- Could transformation mechanisms of acetylase-harboring pMdT1 plasmid be evaluated through proteomic tools in Escherichia coli? Article · Aug 2016
- Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages Article · 17 Mar 2016
- Plasmid Flux in Escherichia coli ST131 Sublineages, Analyzed by Plasmid Constellation Network (PLACNET), a New Method for Plasmid Reconstruction from Whole Genome Sequences Article · 18 Dec 2014
- Dissemination of Cephalosporin Resistance Genes between Escherichia coli Strains from Farm Animals and Humans by Specific Plasmid Lineages Article · 18 Dec 2014
- Plasmid Diversity and Adaptation Analyzed by Massive Sequencing of Escherichia coli Plasmids Article · 21 Nov 2014
- Molecular epidemiology and virulence of Escherichia coli O16:H5-ST131: Comparison with H30 and H30-Rx subclones of O25b:H4-ST131 Article · Nov 2014
- Complete Proteome of a Quinolone-Resistant Salmonella Typhimurium Phage Type DT104B Clinical Strain Article · 15 Aug 2014
- Carbapenem-resistant Pseudomonas aeruginosa strains from a Spanish hospital: Characterization of metallo-beta-lactamases, porin OprD and integrons Article · May 2014
- Resistencia a antibióticos y factores de virulencia en aislados clínicos de Salmonella enterica Article · Jan 2014
- Characterisation of plasmids implicated in the mobilisation of extended-spectrum and AmpC β-lactamase genes in clinical Salmonella enterica isolates and temporal stability of the resistance genotype Article · Aug 2013
- pMdT1, a small ColE1-like plasmid mobilizing a new variant of the aac(6')-Ib-cr gene in Salmonella enterica serovar Typhimurium Article · 29 Jan 2013
- β-Lactamases, transferable quinolone resistance determinants, and class 1 integron-mediated antimicrobial resistance in human clinical Salmonella enterica isolates of non-Typhimurium serotypes Article · Jan 2013
- High clonality and diversity of virulence determinants among blaPSE-positive Salmonella Typhimurim isolates recovered in three geographically distant Spanish hospitals Article · Dec 2012
- Phenotypic and Genotypic Characterization of Salmonella enterica Recovered from Poultry Meat in Tunisia and Identification of New Genetic Traits Article · Jan 2012
- A novel class 1 integron array carrying bla VIM-2 genes and a new insertion sequence in a Pseudomonas aeruginosa strain isolated from a Spanish hospital Article · 1 Jul 2011
- In vivo selection of aac(6′)-Ib-cr and mutations in the gyrA gene in a clinical qnrS1-positive Salmonella enterica serovar Typhimurium DT104B strain recovered after fluoroquinolone treatment Article · 16 Jul 2010
